HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP

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	HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP
	CUI, ZB ; ZHU, ZY
刊名	FISH PHYSIOLOGY AND BIOCHEMISTRY
	1993-08-01
卷号	12 期号:2 页码:161-169
关键词	COMMON CARP CRUCIAN CARP GROWTH HORMONE GROWTH HORMONE GENE TRANSGENIC FISH HORMONAL REPLACEMENT HYPOPHYSECTOMY
ISSN号	0920-1742
英文摘要	Transgenic common carp, Cyprinus carpio, produced by the microinjection of fertilized eggs with a linearized chimeric plasmid pMThGH, a human growth hormone (hGH) gene with a mouse metallothionein-I (MT) gene promoter in pBR322, were used to produce F1 and F2 transgenics. Following hypophysectomy of the transgenic F2 common carp, non-transgenic common carp and non-transgenic crucian carp, growth was monitored for up to 110 days. In addition, recombinant hGH was injected subcutaenously into a group of the non-transgenic crucian carp. Growth rate analyses indicated that (1) hypophysectomy of non-transgenic common carp and crucian carp results in the cessation of growth, (2) hGH administration can stimulate the growth of hypophysectomized crucian carp and (3) hypophysectomized hGH-transgenic common carp continue to grow in the absence of their own growth hormone, suggesting that the hGH-transgene is being expressed in tissues other than the pituitary.
WOS研究方向	Biochemistry & Molecular Biology ; Fisheries ; Physiology
语种	英语
出版者	KUGLER PUBLICATIONS BV
WOS记录号	WOS:A1993LZ11300009
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/4014]
专题	中国科学院武汉植物园
作者单位	1.UNIV ABERDEEN,DEPT MOLEC & CELL BIOL,ABERDEEN AB9 2TN,SCOTLAND 2.CHINESE ACAD SCI,INST HYDROBIOL,WUHAN,HUBEI 430072,PEOPLES R CHINA 3.UNIV ABERDEEN,DEPT ZOOL,ABERDEEN AB9 2TN,SCOTLAND
推荐引用方式 GB/T 7714	CUI, ZB,ZHU, ZY. HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP[J]. FISH PHYSIOLOGY AND BIOCHEMISTRY,1993,12(2):161-169.
APA	CUI, ZB,&ZHU, ZY.(1993).HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP.FISH PHYSIOLOGY AND BIOCHEMISTRY,12(2),161-169.
MLA	CUI, ZB,et al."HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP".FISH PHYSIOLOGY AND BIOCHEMISTRY 12.2(1993):161-169.