National Borders Effectively Halt the Spread of Rabies: The Current Rabies Epidemic in China Is Dislocated from Cases in Neighboring Countries

doi:10.1371/journal.pntd.0002039

CORC > 武汉植物园 > 中国科学院武汉植物园

	National Borders Effectively Halt the Spread of Rabies: The Current Rabies Epidemic in China Is Dislocated from Cases in Neighboring Countries
	Han, Na 2; Guo, Zhenyang 1,2; Tao, Xiaoyan 1; Yin, Cuiping 1; Yu, Jinning 1; Li, Hao 1; Liu, Haizhou 2; Fang, Wei 2; Adams, James 2; Wang, Jun 2
刊名	PLOS NEGLECTED TROPICAL DISEASES
	2013
卷号	7 期号:1 页码:13
ISSN号	1935-2735
DOI	10.1371/journal.pntd.0002039
英文摘要	China has seen a massive resurgence of rabies cases in the last 15 years with more than 25,000 human fatalities. Initial cases were reported in the southwest but are now reported in almost every province. There have been several phylogenetic investigations into the origin and spread of the virus within China but few reports investigating the impact of the epidemic on neighboring countries. We therefore collected nucleoprotein sequences from China and South East Asia and investigated their phylogenetic and phylogeographic relationship. Our results indicate that within South East Asia, isolates mainly cluster according to their geographic origin. We found evidence of sporadic exchange of strains between neighboring countries, but it appears that the major strain responsible for the current Chinese epidemic has not been exported. This suggests that national geographical boundaries and border controls are effective at halting the spread of rabies from China into adjacent regions. We further investigated the geographic structure of Chinese sequences and found that the current epidemic is dominated by variant strains that were likely present at low levels in previous domestic epidemics. We also identified epidemiological linkages between high incidence provinces consistent with observations based on surveillance data from human rabies cases.
资助项目	National Department Public Benefit Research Foundation[201103032] ; Pathogens Network Monitoring Technology Research Program[2008ZX10004-008] ; National Basic Research Program of China[2012CB721100]
WOS研究方向	Infectious Diseases ; Parasitology ; Tropical Medicine
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000314360200057
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/3840]
专题	中国科学院武汉植物园
通讯作者	Guo, Zhenyang
作者单位	1.Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China 2.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Han, Na,Guo, Zhenyang,Tao, Xiaoyan,et al. National Borders Effectively Halt the Spread of Rabies: The Current Rabies Epidemic in China Is Dislocated from Cases in Neighboring Countries[J]. PLOS NEGLECTED TROPICAL DISEASES,2013,7(1):13.
APA	Han, Na.,Guo, Zhenyang.,Tao, Xiaoyan.,Yin, Cuiping.,Yu, Jinning.,...&Rayner, Simon.(2013).National Borders Effectively Halt the Spread of Rabies: The Current Rabies Epidemic in China Is Dislocated from Cases in Neighboring Countries.PLOS NEGLECTED TROPICAL DISEASES,7(1),13.
MLA	Han, Na,et al."National Borders Effectively Halt the Spread of Rabies: The Current Rabies Epidemic in China Is Dislocated from Cases in Neighboring Countries".PLOS NEGLECTED TROPICAL DISEASES 7.1(2013):13.