Analysis of Flavonoids in Rhamnus davurica and Its Antiproliferative Activities

doi:10.3390/molecules21101275

CORC > 武汉植物园 > 中国科学院武汉植物园

	Analysis of Flavonoids in Rhamnus davurica and Its Antiproliferative Activities
	Chen, Guilin 1,2; Li, Xun 1,2; Saleri, Flora 1,2; Guo, Mingquan 2,3
刊名	MOLECULES
	2016-10-01
卷号	21 期号:10 页码:14
关键词	Rhamnus davurica fingerprint profile flavonoids antiproliferative activities HPLC-ESI-MS/MS
ISSN号	1420-3049
DOI	10.3390/molecules21101275
英文摘要	Rhamnus davurica Pall. (R. davurica) has been used as a traditional medicinal herb for many years in China and abroad. It has been well documented as a rich source of flavonoids with diversified structures, which in turn results in far-ranging biological activities, such as anti-inflammation, anticancer, antibacterial and antioxidant activities. In order to further correlate their anticancer potentials with the phytochemical components, the fingerprint profile of R. davurica herb from Dongbei was firstly investigated using HPLC-ESI-MS/MS. Thirty two peaks were detected and identified, 14 of which were found in R. davurica for the first time in this work. Furthermore, a total of 23 peaks were resolved as flavonoids, which are the major components found in R. davurica. Meanwhile, the antiproliferative activities against human cancer cells of HT-29 and SGC-7901 in vitro exhibited distinct inhibitory effects with IC50 values at 24.96 +/- 0.74 and 89.53 +/- 4.11 mu g/mL, respectively. Finally, the general toxicity against L-O2 cells displayed a much higher IC50 at 229.19 +/- 8.52 mu g/mL, which suggested very low or no toxicity on hepatic cell viability. The current study revealed for the first time the correlations between the flavonoids of R. davurica with their antiproliferative activities, which indicated that the fingerprint profile of flavonoids and their anticancer activities could provide valuable information on the quality control for herbal medicines and their derived natural remedies from this valuable medicinal plant.
资助项目	Natural Science Foundation of China[51428303] ; Chinese Academy of Sciences[29Y429291a0129] ; Sino-Africa joint research project[SAJC20160233]
WOS研究方向	Chemistry
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000389917900012
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/3067]
专题	中国科学院武汉植物园
通讯作者	Guo, Mingquan
作者单位	1.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, Sinoafrica Joint Res Ctr, Wuhan 430074, Peoples R China
推荐引用方式 GB/T 7714	Chen, Guilin,Li, Xun,Saleri, Flora,et al. Analysis of Flavonoids in Rhamnus davurica and Its Antiproliferative Activities[J]. MOLECULES,2016,21(10):14.
APA	Chen, Guilin,Li, Xun,Saleri, Flora,&Guo, Mingquan.(2016).Analysis of Flavonoids in Rhamnus davurica and Its Antiproliferative Activities.MOLECULES,21(10),14.
MLA	Chen, Guilin,et al."Analysis of Flavonoids in Rhamnus davurica and Its Antiproliferative Activities".MOLECULES 21.10(2016):14.