Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients

	Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients
	Xu, G ; Di Stefano, C ; Liebich, HM ; Zhang, Y ; Lu, P
刊名	journal of chromatography b
	1999-09-24
卷号	732 期号:2 页码:307-313
关键词	pattern recognition nucleosides
英文摘要	post-transcriptional modifications in rna give rise to free modified ribonucleosides circulating in the blood stream and excreted in urine. due to their abnormal levels in conjunction with several tumor diseases, they have been suggested as possible tumor markers. the developed rp-hplc method has been applied to analyze the urinary nucleosides in 34 urinary samples from 15 kinds of cancer patients. the statistical analyses showed the urinary nucleoside excretion, especially modified nucleoside levels, in cancer patients were significantly higher than those in normal healthy volunteers. factor analysis was used to classify the patients with cancer and normal healthy humans. it was found that using 15 urinary nucleoside levels or only five modified nucleoside levels as data vectors the factor analysis plot displayed two almost separate clusters representing each group. (c) 1999 elsevier science b.v. all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	tumor-marker ; capillary electrophoresis ; rna turnover ; excretion ; pseudouridine ; quantitation ; carcinoma ; leukemia ; lung
收录类别	SCI
原文出处	true
语种	英语
WOS记录号	WOS:000082839700006
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/86241]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China 2.Univ Tubingen, Med Klin, D-72076 Tubingen, Germany
推荐引用方式 GB/T 7714	Xu, G,Di Stefano, C,Liebich, HM,et al. Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients[J]. journal of chromatography b,1999,732(2):307-313.
APA	Xu, G,Di Stefano, C,Liebich, HM,Zhang, Y,&Lu, P.(1999).Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients.journal of chromatography b,732(2),307-313.
MLA	Xu, G,et al."Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients".journal of chromatography b 732.2(1999):307-313.