Bioinspired Synthesis of Nitriles from Primary Amides via Zinc/Anhydride Catalysis | |
Wang, Yuanyuan1,2; Fu, Liyan2; Qi, Huimin1,2; Chen, Shu-Wei1; Li YH(李跃辉)2; Li YH(李跃辉) | |
刊名 | Asian Journal of Organic Chemistry
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2018 | |
卷号 | 7期号:2页码:367-370 |
关键词 | Amides Anhydrides Cooperative Catalysis Hydrosilanes Nitriles |
ISSN号 | 2193-5807 |
DOI | 10.1002/ajoc.201700664 |
英文摘要 | A broad scope of aromatic and aliphatic primary amides were converted to their corresponding nitriles in high yields by using polymethylhydrosiloxane (PMHS) in the presence of catalytic amounts of ZnBr2 and propylphosphonic anhydride (T3P). As an example of dehydration reaction promoted by anhydrides, ZnBr2 and T3P cooperatively activate the amide substrate and the silane to allow the desired dehydration to occur smoothly under mild conditions. Moreover, this method is suitable for the condensation reaction of carboxylic acids with amines to give the corresponding amide products, including a key intermediate of cinacalcet. |
学科主题 | 物理化学与绿色催化 |
语种 | 英语 |
WOS记录号 | WOS:000425000600016 |
资助机构 | National Program for Thousand Young Talents of China, NNSFC (21202131;21633013;21602228);NSF of Jiangsu Province (BK20160394);the Special Innovation Funding of LICP |
内容类型 | 期刊论文 |
源URL | [http://ir.licp.ac.cn/handle/362003/23706] ![]() |
专题 | 兰州化学物理研究所_苏州研究院 兰州化学物理研究所_OSSO国家重点实验室 |
通讯作者 | Chen, Shu-Wei; Li YH(李跃辉) |
作者单位 | 1.Northwest A&F Univ, Coll Chem & Pharm, Yangling 712100, Peoples R China 2.Chinese Acad Sci, LICP, Suzhou Res Inst, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yuanyuan,Fu, Liyan,Qi, Huimin,et al. Bioinspired Synthesis of Nitriles from Primary Amides via Zinc/Anhydride Catalysis[J]. Asian Journal of Organic Chemistry,2018,7(2):367-370. |
APA | Wang, Yuanyuan,Fu, Liyan,Qi, Huimin,Chen, Shu-Wei,Li YH,&李跃辉.(2018).Bioinspired Synthesis of Nitriles from Primary Amides via Zinc/Anhydride Catalysis.Asian Journal of Organic Chemistry,7(2),367-370. |
MLA | Wang, Yuanyuan,et al."Bioinspired Synthesis of Nitriles from Primary Amides via Zinc/Anhydride Catalysis".Asian Journal of Organic Chemistry 7.2(2018):367-370. |
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