Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets

	Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets
	Wu, Zhijian ; Jiang, Yan ; Kim, Taehoon ; Lee, Kangtaek
刊名	JOURNAL OF CONTROLLED RELEASE
	2007-06-01
卷号	119 期号:2 页码:215-221
关键词	Mesoporous Silica Vitamin B-1 Organosilane Coating Controlled Release
文献子类	Article
英文摘要	The controlled release of vitamin B-1 (VB1, thiamine hydrochloride) from mesoporous silica tablets coated with a series of sol-gel coatings was investigated. Tetraethoxysilane (TEOS), n-propyltrietboxysilane (PTES), n-octyltriethoxysilane (OTES), bis(trimethoxysilyl)hexane (TSH), his (triethoxysilyl)octane (TSO), bis (trimethoxysilylpropyl)amine (TSPA), and bis[(3-trimethoxysilyl)propyl]ethylenediamine (TSPED) were used as precursors for the coatings. The effects of organosilane type and concentration, the number of coatings, drying temperature, and release media on VB1 release from the coated mesoporous silica tablets were comprehensively examined. The TSH, TSO, TSPA, and TSPED coatings were found to be more effective in suppression of release than the other coatings. VB1 release decreases with the increase in the number of coatings and drying temperature. It was found that there is an optimal coating solution concentration for the controlled release. In general, more VB1 is released in 0.01 M HCl solution than in 0.05 M phosphate buffer solution at pH 7.4 because of the electrostatic repulsions between the protonated VB1 cations and the positively charged mesoporous silica carrier/coatings. The experimental results show that drug release can be easily controlled by changing the organosilane type and the number of coating. The method used in this study is an effective and flexible way for controlled release due to the high drug loading and the easy control of release rate. (C) 2007 Elsevier B.V. All rights reserved.
WOS关键词	CONTROLLED DRUG-DELIVERY ; IN-VITRO RELEASE ; DOPED HYBRID XEROGELS ; SOL-GEL ; SYNTHESIS PARAMETERS ; DYE ADSORPTION ; PORE STRUCTURE ; CARRIER ; MCM-41 ; PROPERTY
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000247192800009
内容类型	期刊论文
源URL	[http://ir.isl.ac.cn/handle/363002/5819]
专题	中国科学院青海盐湖研究所青海盐湖研究所_青海盐湖研究所知识仓储青海盐湖研究所_盐湖资源与化学实验室
作者单位	1.Huaqiao Univ, Coll Mat Sci & Engn, Quanzhou 362021, Peoples R China 2.Chinese Acad Sci, Qinghai Inst Salt Lakes, Xining 810008, Peoples R China 3.Yonsei Univ, Dept Chem Engn, Seoul 120749, South Korea
推荐引用方式 GB/T 7714	Wu, Zhijian,Jiang, Yan,Kim, Taehoon,et al. Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets[J]. JOURNAL OF CONTROLLED RELEASE,2007,119(2):215-221.
APA	Wu, Zhijian,Jiang, Yan,Kim, Taehoon,&Lee, Kangtaek.(2007).Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets.JOURNAL OF CONTROLLED RELEASE,119(2),215-221.
MLA	Wu, Zhijian,et al."Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets".JOURNAL OF CONTROLLED RELEASE 119.2(2007):215-221.