Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer

doi:10.1016/j.biomaterials.2017.04.028

	Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer
	Sun, Lijun 1,3; Wang, Dangge 2; Chen, Yu 1; Wang, Liying 1,3; Huang, Ping 1; Li, Yaping 2; Liu, Ziwei 1; Yao, Heliang 1; Shi, Jianlin 1
刊名	Biomaterials
	2017
卷号	133 页码:219-228
ISSN号	01429612
DOI	10.1016/j.biomaterials.2017.04.028
英文摘要	The design and synthesis of hierarchically nanoporous structures for the co-encapsulation and sequential releases of different cargos are still great challenges in biomedical applications. In this work, we report on the elaborate design and controlled synthesis of a unique core-shell hierarchical mesoporous silica/organosilica nanosystem, in which there are large and small mesopores separately present in the shell and core, facilitating the independent encapsulations of large (siRNA) and small (doxorubicin) molecules, respectively. Importantly, the framework of the organosilica shell is molecularly hybridized with disulfide bonds, which enables the unique responsiveness to the reductive tumor microenvironment for the controlled releasing of loaded gene molecules, followed by the subsequent doxorubicin release. The first released large siRNA molecules from the organosilica shell down-regulated the expression of P-gp in the cell membrane and reversed the MDR of cancer cells, thus enhancing the antitumor effect of subsequently released small DOX molecules from the silica core, and in such a synergetic way the MDR tumor growth can be efficiently inhibited. This work shows the significant advantages compared to the traditional small-mesoporous or large-mesoporous nanosystems for drug co-delivery. © 2017 Elsevier Ltd
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25406]
专题	中国科学院上海硅酸盐研究所
作者单位	1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai; 200050, China; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai; 201203, China; 3.University of Chinese Academy of Sciences, Beijing; 100049, China
推荐引用方式 GB/T 7714	Sun, Lijun,Wang, Dangge,Chen, Yu,et al. Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer[J]. Biomaterials,2017,133:219-228.
APA	Sun, Lijun.,Wang, Dangge.,Chen, Yu.,Wang, Liying.,Huang, Ping.,...&Shi, Jianlin.(2017).Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer.Biomaterials,133,219-228.
MLA	Sun, Lijun,et al."Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer".Biomaterials 133(2017):219-228.