Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold

doi:10.1002/jbm.b.33924

	Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold
	Fu, Qiang 1; Jia, Weitao 2; Lau, Grace Y.1; Tomsia, Antoni P.1
刊名	Journal of Biomedical Materials Research - Part B Applied Biomaterials
	2018
卷号	106 期号:3 页码:1209-1217
ISSN号	15524973
DOI	10.1002/jbm.b.33924
英文摘要	Development of bioactive glass and ceramic scaffolds intended for the reconstruction of large segmental bone defects remains a challenge for materials science due to the complexities involved in clinical implantation, bone–implant reaction, implant degradation and the multiple loading modes the implants subjected to. A comprehensive evaluation of the mechanical properties of inorganic scaffolds and exploration of new ways to toughen brittle constructs are critical prior to their successful application in loaded sites. A simple and widely adopted approach involves the coating of an inorganic scaffold with a polymeric material. In this work, a systematic evaluation of the influence of a biopolymer, polycaprolactone (PCL), coating on the mechanical performance of bioactive glass scaffolds was carried out. Results from this work indicate that a biopolymer PCL coating was more effective in increasing the compressive strength and reliability of the glass scaffold under compression, but less effective in improving its flexural strength or fracture toughness. This is the first report that reveals the limited successfulness of a polymer coating in improving the toughness of strong scaffolds, suggesting that new and novel ways of toughening inorganic scaffolds should be future research directions for scaffolds applied in loaded sites. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1209–1217, 2018. © 2017 Wiley Periodicals, Inc.
出版者	John Wiley and Sons Inc., P.O.Box 18667, Newark, NJ 07191-8667, United States
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25340]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley; CA; 94720, United States; 2.Department of Orthopedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai; 200233, China
推荐引用方式 GB/T 7714	Fu, Qiang,Jia, Weitao,Lau, Grace Y.,et al. Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold[J]. Journal of Biomedical Materials Research - Part B Applied Biomaterials,2018,106(3):1209-1217.
APA	Fu, Qiang,Jia, Weitao,Lau, Grace Y.,&Tomsia, Antoni P..(2018).Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold.Journal of Biomedical Materials Research - Part B Applied Biomaterials,106(3),1209-1217.
MLA	Fu, Qiang,et al."Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold".Journal of Biomedical Materials Research - Part B Applied Biomaterials 106.3(2018):1209-1217.