Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor

doi:10.1039/c7tb03076b

	Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor
	Wang, Ruizhi ; Luo, Yu 1; Li, Xin 2; Ji, Aihua ; Guo, Rongfang ; Shi, Xiangyang 2; Wang, Xiaolin
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2018
卷号	6 期号:9 页码:1342
ISSN号	2050-750X
DOI	10.1039/c7tb03076b
英文摘要	The development of an ultrasensitive nanoprobe is regarded as one of the most promising strategies for the precise diagnosis of tumors. Herein, tanespimycin (17-AAG)-modified polyethylenimine-based gold nanoparticles (AuNPs) co-labeled with a gadolinium (Gd) nanoprobe are constructed for targeted dual-mode computed tomography (CT)/magnetic resonance (MR) imaging. The specific binding of tanespimycin to the N-terminal of heat shock protein 90 (HSP90) endows the modified nanoprobes (NPs) with the ability to up-regulate HSP90 tumor cells and to display excellent X-ray attenuation intensity and T-1 MR imaging performance in an orthotopic hepatocellular carcinoma tumor model. Such an ultrasensitive nanoprobe holds enormous promise for highly efficient tumor diagnosis and dual-mode CT/T-1 positive MR imaging. This study develops a novel strategy to prepare a multifunctional nanoprobe via polyethylenimine nanotechnology. Using this strategy, various dual-mode or multimode nanoprobes for diagnosing different cancers may be designed.
学科主题	Materials Science, bioMaterials
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000426706900006
资助机构	This research was financially supported by the National Natural Science Foundation of China (51602334, 21273032 and 81371623), the Sino-German Center for Research Promotion (GZ899), and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. ; This research was financially supported by the National Natural Science Foundation of China (51602334, 21273032 and 81371623), the Sino-German Center for Research Promotion (GZ899), and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25106]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Fudan Univ, Shanghai Inst Med Imaging, Zhongshan Hosp, Dept Intervent, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China 3.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ruizhi,Luo, Yu,Li, Xin,et al. Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(9):1342, 1350.
APA	Wang, Ruizhi.,Luo, Yu.,Li, Xin.,Ji, Aihua.,Guo, Rongfang.,...&Wang, Xiaolin.(2018).Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor.JOURNAL OF MATERIALS CHEMISTRY B,6(9),1342.
MLA	Wang, Ruizhi,et al."Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor".JOURNAL OF MATERIALS CHEMISTRY B 6.9(2018):1342.