Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy

doi:10.1039/c7cs00471k

	Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
	Lin, Han 1; Chen, Yu ; Shi, Jianlin
刊名	CHEMICAL SOCIETY REVIEWS
	2018
卷号	47 期号:6 页码:1938
ISSN号	0306-0012
DOI	10.1039/c7cs00471k
英文摘要	Tumour chemotherapy employs highly cytotoxic chemodrugs, which kill both cancer and normal cells by cellular apoptosis or necrosis non-selectively. Catalysing/triggering the specific chemical reactions only inside tumour tissues can generate abundant and special chemicals and products locally to initiate a series of unique biological and pathologic effects, which may enable tumour-specific theranostic effects to combat cancer without bringing about significant side effects on normal tissues. Nevertheless, chemical reaction-initiated selective tumour therapy strongly depends on the advances in chemistry, materials science, nanotechnology and biomedicine. This emerging cross-disciplinary research area is substantially different from conventional cancer-theranostic modalities in clinics. In response to the fast developments in cancer theranostics based on intratumoural catalytic chemical reactions, this tutorial review summarizes the very-recent research progress in the design and synthesis of representative nanoplatforms with intriguing nanostructures, compositions, physiochemical properties and biological behaviours for versatile catalytic chemical reaction-enabled cancer treatments, mainly by either endogenous tumour microenvironment (TME) triggering or exogenous physical irradiation. These unique intratumoural chemical reactions can be used in tumour-starving therapy, chemodynamic therapy, gas therapy, alleviation of tumour hypoxia, TME-responsive diagnostic imaging and stimuli-responsive drug release, and even externally triggered versatile therapeutics. In particular, the challenges and future developments of such a novel type of cancer-theranostic modality are discussed in detail to understand the future developments and prospects in this research area as far as possible. It is highly expected that this kind of unique tumour-specific therapeutics by triggering specific in situ catalytic chemical reactions inside tumours would provide a novel but efficient methodology for benefiting personalized biomedicine in combating cancer.
学科主题	Chemistry, Multidisciplinary
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000429201500002
资助机构	We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant No. 51722211 and 51672303), Natural Science Foundation of Shanghai (Grant No. 13ZR1463500) and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). ; We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant No. 51722211 and 51672303), Natural Science Foundation of Shanghai (Grant No. 13ZR1463500) and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25084]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lin, Han,Chen, Yu,Shi, Jianlin. Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy[J]. CHEMICAL SOCIETY REVIEWS,2018,47(6):1938, 1958.
APA	Lin, Han,Chen, Yu,&Shi, Jianlin.(2018).Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy.CHEMICAL SOCIETY REVIEWS,47(6),1938.
MLA	Lin, Han,et al."Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy".CHEMICAL SOCIETY REVIEWS 47.6(2018):1938.