Bioglass Activated Albumin Hydrogels for Wound Healing

doi:10.1002/adhm.201800144

	Bioglass Activated Albumin Hydrogels for Wound Healing
	Zhou, Yanling ; Gao, Long ; Peng, Jinliang 1; Xing, Min ; Han, Yan ; Wang, Xiaoya ; Xu, Yuhong 1; Chang, Jiang
刊名	ADVANCED HEALTHCARE MATERIALS
	2018
卷号	7 期号:16
关键词	albumin bioglass inorganic organic composite hydrogels microdialysis wound healing
ISSN号	2192-2640
DOI	10.1002/adhm.201800144
英文摘要	In this study, a novel Bioglass/albumin composite hydrogel with controllable injectability, good adhesiveness, and bioactivity, is developed by utilizing dual-functional bioactive ions released from Bioglass, which on one side controls the gelling time by creating an alkaline environment to regulate the cross-linking reaction between human serum albumin and succinimidyl succinate modified poly(ethylene glycol), and on the other side stimulates wound healing. The composite hydrogel exhibits adhesive property that is superior to clinically used fibrin and cyanoacrylate glues. The gelation time of the composite hydrogel could be regulated via changing the amounts of Bioglass which endows the hydrogel with good injectability. The in vivo experiment confirms that this composite hydrogel has good bioactivity to stimulate angiogenesis and enhance chronic wound healing. Moreover, for the first time, the concentrations of the bioactive ions released from the composite hydrogel in situ are quantified during wound healing using a microdialysis technique, and a correlation of the in vitro and in vivo concentration of ions released from the hydrogel is determined, which is extremely important for understanding the bioactivity mechanisms of Bioglass/bioceramic-based biomaterials and designing biomaterials for tissue regeneration.
学科主题	Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, bioMaterials
出版者	WILEY
WOS记录号	WOS:000442338600007
资助机构	This work was supported by the National Key Research and Development Plan of China (No. 2016YFC1100201). The authors gratefully acknowledged the materials supports from Hangzhou Yahui Biological Technology Co., Ltd. ; This work was supported by the National Key Research and Development Plan of China (No. 2016YFC1100201). The authors gratefully acknowledged the materials supports from Hangzhou Yahui Biological Technology Co., Ltd.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24721]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yanling,Gao, Long,Peng, Jinliang,et al. Bioglass Activated Albumin Hydrogels for Wound Healing[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(16).
APA	Zhou, Yanling.,Gao, Long.,Peng, Jinliang.,Xing, Min.,Han, Yan.,...&Chang, Jiang.(2018).Bioglass Activated Albumin Hydrogels for Wound Healing.ADVANCED HEALTHCARE MATERIALS,7(16).
MLA	Zhou, Yanling,et al."Bioglass Activated Albumin Hydrogels for Wound Healing".ADVANCED HEALTHCARE MATERIALS 7.16(2018).