Sensitive detection of free bilirubin in blood serum using beta-diketone modified europium-doped yttrium oxide nanosheets as a luminescent sensor

doi:10.1039/c8ra02817f

	Sensitive detection of free bilirubin in blood serum using beta-diketone modified europium-doped yttrium oxide nanosheets as a luminescent sensor
	Yang, Wei ; Xia, Jinfeng 1; Zhou, Guohong 1; Jiang, Danyu 1; Li, Qiang
刊名	RSC ADVANCES
	2018
卷号	8 期号:32 页码:17854
ISSN号	2046-2069
DOI	10.1039/c8ra02817f
英文摘要	Free bilirubin, when present in excess in the human body, can cause a multitude of diseases and disorders and even be fatal; hence, detecting it is of paramount importance. Herein, we report a luminescence quenching-based non-enzymatic method for the convenient, reliable, and rapid detection of free bilirubin in blood serum samples using sensing films (nanosheets/PS, nanosheets-tta/PS, and nanosheets-dbt/PS) as luminescent sensors. The luminescence intensity of the sensing films is linearly related to the free bilirubin concentration. Nanosheets-tta/PS demonstrated excellent sensing properties for the sensitive and reliable detection of free bilirubin in the range of 0.0-60.0 mu M with a correlation coefficient of 0.9915, as compared to nanosheets/PS or nanosheets-dbt/PS. The limit of detection for the determination of free bilirubin was 41 nM. This method can be used to design a sensor-based test spot as a medical detection device for the visual detection of free bilirubin.
学科主题	Chemistry, Multidisciplinary
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000435824500027
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24570]
专题	中国科学院上海硅酸盐研究所
作者单位	1.East China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Yang, Wei,Xia, Jinfeng,Zhou, Guohong,et al. Sensitive detection of free bilirubin in blood serum using beta-diketone modified europium-doped yttrium oxide nanosheets as a luminescent sensor[J]. RSC ADVANCES,2018,8(32):17854, 17859.
APA	Yang, Wei,Xia, Jinfeng,Zhou, Guohong,Jiang, Danyu,&Li, Qiang.(2018).Sensitive detection of free bilirubin in blood serum using beta-diketone modified europium-doped yttrium oxide nanosheets as a luminescent sensor.RSC ADVANCES,8(32),17854.
MLA	Yang, Wei,et al."Sensitive detection of free bilirubin in blood serum using beta-diketone modified europium-doped yttrium oxide nanosheets as a luminescent sensor".RSC ADVANCES 8.32(2018):17854.