Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling

doi:10.1016/j.ceramint.2017.11.058

	Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling
	Zhou, Yanling ; Xu, Chen ; Wang, Xiaoya ; Dou, Yuandong 2; Huan, Zhiguang ; Chang, Jiang 1
刊名	CERAMICS INTERNATIONAL
	2018
卷号	44 期号:3 页码:3015
关键词	Tricalcium silicate Magnesium phosphate cement Premixed cements Dental application
ISSN号	0272-8842
DOI	10.1016/j.ceramint.2017.11.058
英文摘要	MTA-based root-end filling is a promising therapeutic approach for root repair, however, difficult handling characteristics, presence of toxic elements in the material composition and long setting time are main drawbacks for clinical applications. The purpose of this study was to develop a novel fast setting silicate based premixed cement for endodontic use. The premixed cement contained tricalcium silicate (C3S) as the main constituent for hydration, magnesium phosphate cement (MPC) as setting accelerators and glycerol as water-miscible liquid. The physicochemical properties and antibacterial property of the novel cements were evaluated. Moreover, biocompatible zirconium oxide (ZrO2) was chosen as radiopacifying agent added into the premixed cement. The radiopacity, physicochemical properties, antibacterial property and cytotoxicity of the radiopaque premixed calcium silicate based cements were evaluated. The setting time of the premixed MPC/C3S cements could be modulated within the range from 70 min to 205 min by adjusting the content of MPC. Meanwhile, the premixed MPC/C3S cement displayed good flowability and injectability when the amount of MPC less than 20%. The addition of ZrO2 provided the premixed MPC/C3S cement with excellent radiopacity while had no significant effects on the setting time, flowability, film thickness, injectability and washout resistance. Moreover, the premixed cement with or without ZrO2 had good antibacterial property and cytotoxicity. Our results indicated that the premixed MPC/C3S/ZrO2 cement could be considered as a promising candidate for application in endodontics owing to its desirable physicochemical properties, antibacterial activity and cytocompatibility, especially relatively short setting time and good sealing ability.
学科主题	Materials Science, Ceramics
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000423891900051
资助机构	We acknowledged the financial support from National Natural Science Foundation of China (Nos. 81671830 and 81401529). ; We acknowledged the financial support from National Natural Science Foundation of China (Nos. 81671830 and 81401529).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24474]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Med Res Inst 10, Sch Biomed Engn, 1954 Huashan Rd, Shanghai 200030, Peoples R China 3.Yantai Zhenghai Biotech Co Ltd, 10 Hengshan Rd, Yantai 264006, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yanling,Xu, Chen,Wang, Xiaoya,et al. Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling[J]. CERAMICS INTERNATIONAL,2018,44(3):3015, 3023.
APA	Zhou, Yanling,Xu, Chen,Wang, Xiaoya,Dou, Yuandong,Huan, Zhiguang,&Chang, Jiang.(2018).Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling.CERAMICS INTERNATIONAL,44(3),3015.
MLA	Zhou, Yanling,et al."Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling".CERAMICS INTERNATIONAL 44.3(2018):3015.