Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing

doi:10.1016/j.ijbiomac.2018.02.075

	Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing
	Xie, Yu 1,3,4; Yi, Zeng-xing 1,3,4; Wang, Jian-xun 2,3,4; Hou, Tong-gang 2,3,4; Jiang, Qiong 1,3,4
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2018-06-01
卷号	112 页码:1225-1233
关键词	Cmkgm Sponge Wound Dressing
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2018.02.075
文献子类	Article
英文摘要	In this paper, carboxymethyl konjac glucomannan (CMKGM) was obtained by carboxyl modification of konjac glucomannan. Then CMKGM and chitosan (CS) were crosslinked and freeze-dried to prepare CMKGM/CS composite sponges with different proportions. The structure and micromorphology of CMKGM/CS sponges were investigated by FTIR spectroscopy and SEM. The SEM results showed that the pore structure of the composite sponge gradually increased with the increase of CMKGM content To assess the applicability of CMKGM/CS composite sponges as wound dressing, the swelling behavior, water vapor transmission rate (WVYR), biocompatibility (cytotoxicity and hemolysis) were analyzed. The results indicated that CMKGM/CS composite sponges possessed high swelling ratio, proper WVTR and good biocompatibility, which might accelerate tissue regeneration. Meanwhile, in vivo experiments demonstrated that CMKGM/CS composite sponges could effectively heal full-layer wound of skin defects of male ICR mice. (C) 2018 Elsevier B.V. All rights reserved.
WOS关键词	HYDROGEL ; DERIVATIVES ; BIOMATERIALS ; CELLULOSE ; CHITIN ; FILMS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000430522400144
资助机构	Open foundation of Key Laboratory of biological base materials, Chinese Academy of Sciences ; Yichun science and technology innovation platform and innovation team plan project(20160609) ; project of local development research center of Yichun University(2016025)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/11501]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Jiang, Qiong
作者单位	1.Yichun Univ, Coll Chem & Bioengn, Yichun 336000, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 3.Chinese Acad Sci, Joint Res Ctr, Qingdao Inst Bioenergy & Bioproc Technol, Yichun 336000, Peoples R China 4.Yichun Univ, Yichun 336000, Peoples R China
推荐引用方式 GB/T 7714	Xie, Yu,Yi, Zeng-xing,Wang, Jian-xun,et al. Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,112:1225-1233.
APA	Xie, Yu,Yi, Zeng-xing,Wang, Jian-xun,Hou, Tong-gang,&Jiang, Qiong.(2018).Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,112,1225-1233.
MLA	Xie, Yu,et al."Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 112(2018):1225-1233.