Dotted Core-Shell Nanoparticles for T-1-Weighted MRI of Tumors

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2018专题

	Dotted Core-Shell Nanoparticles for T-1-Weighted MRI of Tumors
	Niu, Gang; Wu, Aiguo; Chen, Xiaoyuan; Shen, Zheyu; Song, Jibin; Zhou, Zijian; Yung, Bryant C.; Aronova, Maria A.; Li, Yan; Dai, Yunlu
刊名	ADVANCED MATERIALS
	2018
卷号	30 期号:33
关键词	Energy-loss Spectroscopy Iron-oxide Nanoparticles In-vivo Contrast Agents Cancer Cells T-1 Relaxivity Diagnosis Efficacy
英文摘要	Gd-based T-1-weighted contrast agents have dominated the magnetic resonance imaging (MRI) contrast agent market for decades. Nevertheless, they are reported to be nephrotoxic and the U.S. Food and Drug Administration has issued a general warning concerning their use. In order to reduce the risk of nephrotoxicity, the MRI performance of the Gd-based T-1-weighted contrast agents needs to be improved to allow a much lower dosage. In this study, novel dotted core-shell nanoparticles (FeGd-HN3-RGD2) with superhigh r(1) value (70.0 mM(-1) s(-1)) and very low r(2)/r(1) ratio (1.98) are developed for high-contrast T-1-weighted MRI of tumors. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and histological analyses show good biocompatibility of FeGd-HN3-RGD2. Laser scanning confocal microscopy images and flow cytometry demonstrate active targeting to integrin alpha(v)beta(3) positive tumors. MRI of tumors shows high tumor Delta SNR for FeGd-HN3-RGD2 (477 +/- 44%), which is about 6-7-fold higher than that of Magnevist (75 +/- 11%). MRI and inductively coupled plasma results further confirm that the accumulation of FeGd-HN3-RGD2 in tumors is higher than liver and spleen due to the RGD2 targeting and small hydrodynamic particle size (8.5 nm), and FeGd-HN3-RGD2 is readily cleared from the body by renal excretion.
学科主题	Science & Technology - Other Topics ; Materials Science
语种	英语
公开日期	2018-12-04
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/17256]
专题	2018专题
推荐引用方式 GB/T 7714	Niu, Gang,Wu, Aiguo,Chen, Xiaoyuan,et al. Dotted Core-Shell Nanoparticles for T-1-Weighted MRI of Tumors[J]. ADVANCED MATERIALS,2018,30(33).
APA	Niu, Gang.,Wu, Aiguo.,Chen, Xiaoyuan.,Shen, Zheyu.,Song, Jibin.,...&Lin, Lisen.(2018).Dotted Core-Shell Nanoparticles for T-1-Weighted MRI of Tumors.ADVANCED MATERIALS,30(33).
MLA	Niu, Gang,et al."Dotted Core-Shell Nanoparticles for T-1-Weighted MRI of Tumors".ADVANCED MATERIALS 30.33(2018).