Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2018专题

	Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach
	Wang, Hui; Hou, Wenjia; Liu, Fu; Han, Qiu; Li, Tiantian; Lin, Haibo; Deng, Gang; He, Jidong
刊名	JOURNAL OF MEMBRANE SCIENCE
	2018
卷号	563 页码:115-125
关键词	Polyethersulfone Membranes Antifouling Properties Polylactide Membrane Polymeric Membranes Heparin Hemodialysis Hemocompatibility Anticoagulant Cytocompatibility Conjugation
英文摘要	It is challenging to improve the hemocompatibility of commercial dialyzers packaging more than 10,000 fibers. Herein, we report the preparation and evaluation of a self-anticlotting Polysulfone dialyzer via an interface crosslinking approach. By modulating the conformation of sulfate, carboxyl groups and pyrrolidone (VP) in heparin-like polymers, the hemocompatibility of the dialyzer was significantly improved. It was found that the sequential structure of functional groups influenced the anticoagulant performances substantially. The hollow fiber modified by the blended polymer (Poly (N-vinyl-2-pyrrolidone-co-triethoxyvinylsilane) and poly (Sodium 4-vinylbenzenssulfonate-co-triethoxyvinylsilane-co-Acrylic acid) (P(VP-VTES)-b-P(SSNa-VTES-AA))) exhibited better hemocompatibility than the contrast membrane modified by poly (Acrylic acid-co-triethoxyvinylsilane-co -N-vinyl-2-pyrrolidone-co--co-Sodium 4-vinylbenzenssulfonate) (P(AA-VTES-VP-SSNa)). The chemical composition was determined by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectra (FTIR). The morphology of the hollow fiber membranes was observed by a scanning electron microscopy (SEM). The thrombin time (TT), plasma fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT) and protein adsorption were measured to examine the hemocompatibility. The modified hollow fiber showed self-anticlotting properties with excellent protein resistance, remarkably prolonged coagulation time (APTT> 600 s), suppressed complement activation and nontoxicity to osteoblasts. The modified dialyzer showed practicable ultrafiltration coefficient and clearance performance, indicating its great potential application in dialysis treatment.
学科主题	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
公开日期	2018-12-04
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/17169]
专题	2018专题
推荐引用方式 GB/T 7714	Wang, Hui,Hou, Wenjia,Liu, Fu,et al. Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach[J]. JOURNAL OF MEMBRANE SCIENCE,2018,563:115-125.
APA	Wang, Hui.,Hou, Wenjia.,Liu, Fu.,Han, Qiu.,Li, Tiantian.,...&He, Jidong.(2018).Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach.JOURNAL OF MEMBRANE SCIENCE,563,115-125.
MLA	Wang, Hui,et al."Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach".JOURNAL OF MEMBRANE SCIENCE 563(2018):115-125.