Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging

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	Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging
	Xiang, Lingchao; Li, Juan; Tian, Yuchen; Shan, Dingying; Gong, An; Zeng, Leyong; Ren, Wenzhi; Gerhard, Ethan; Zhao, Jinshun; Yang, Jian
刊名	BIOMATERIALS
	2017
卷号	116 页码:106-117
ISSN号	0142-9612
英文摘要	Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetrade-cafluorohexane (C6F14) within biodegradable photoluminescent polymers (BPLPs) through an emulsion evaporation process and conjugation of PNBL-NPY ligand for specific targeting of Y-1 receptors overexpressed in breast tumors. The developed PNBL-NPY modified NBs were uniform in size with good dispersibility and photostability, presenting good ultrasound enhancement. Further, in vitro and in vivo results indicated that the fabricated NBs exhibit high affinity and specificity to Y-1 receptor-overexpressing breast cancer cells and tumors with minimal toxicity and damage to organs. Our developed PNBL-NPY-modified NBs are novel targeted UCAs for safe, efficient and specific targeted breast cancer imaging, and may provide a new nanoplatform for early cancer diagnosis and treatment in the future. (C) 2016 Elsevier Ltd. All rights reserved.
公开日期	2017-12-25
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/14006]
专题	2017专题
推荐引用方式 GB/T 7714	Xiang, Lingchao,Li, Juan,Tian, Yuchen,et al. Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging[J]. BIOMATERIALS,2017,116:106-117.
APA	Xiang, Lingchao.,Li, Juan.,Tian, Yuchen.,Shan, Dingying.,Gong, An.,...&Wu, Aiguo.(2017).Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging.BIOMATERIALS,116,106-117.
MLA	Xiang, Lingchao,et al."Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging".BIOMATERIALS 116(2017):106-117.