The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)

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	The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)
	Li, Bin; Su, Lanlan; Lu, Cheng; Yan, Peng; Zhang, Nan; Cai, Sheng; Zhang, Gongjun; Zhou, Xingfei
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2017
卷号	49 期号:4 页码:355-360
ISSN号	1672-9145
英文摘要	Metal ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which is believed to be closely associated with beta-cell death in type II diabetes. In this work, the effect of Al3+ on the aggregation of hIAPP (11-28) was studied by several different experimental approaches. Atomic force microscopy measurements showed that Al3+ could remarkably inhibit hIAPP(11-28) fibrillogenesis, while Zn2+ had a slight promotion effect on peptide aggregation, which was also confirmed by Thioflavin T fluorescence observation. Furthermore, X-ray photoelectron spectroscopy measurement indicated that Al ions might form chemical bonds with neighboring atoms and destroy the secondary structures of the protein. Our studies could deepen the understanding of the role of metal ions in the aggregation of amyloid peptides.
公开日期	2017-12-25
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/13903]
专题	2017专题
推荐引用方式 GB/T 7714	Li, Bin,Su, Lanlan,Lu, Cheng,et al. The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2017,49(4):355-360.
APA	Li, Bin.,Su, Lanlan.,Lu, Cheng.,Yan, Peng.,Zhang, Nan.,...&Zhou, Xingfei.(2017).The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28).ACTA BIOCHIMICA ET BIOPHYSICA SINICA,49(4),355-360.
MLA	Li, Bin,et al."The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 49.4(2017):355-360.