Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2017专题

	Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer
	Ren, Wenzhi; Iqbal, M. Zubair; Zeng, Leyong; Chen, Tianxiang; Pan, Yuanwei; Zhao, Jinshun; Yin, Hao; Zhang, Lili; Zhang, Jichao; Li, Aiguo
刊名	NANOSCALE
	2017
卷号	9 期号:31 页码:11195-11204
ISSN号	2040-3364
英文摘要	TiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980 nm NIR triggered cancer synergistic platforms. However, traditional pure TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR on normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO(2)) coated black TiO2 core-shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer. Properties of the nanocomposites such as micro-morphology, size, drug loading ability and release, targeting performance, and therapy efficiency in vitro and in vivo were evaluated. The results indicated the core-shell nanocomposites with dramatically increased loading ability were pH-responsive/NIR-accelerated doxorubicin release nanocarriers and showed synergistic breast cancer treatment in vitro and in vivo. This study verifies that the newly prepared mSiO(2) coated black TiO2 core-shell nanocarriers can overcome the limitations of traditional TiO2 nanocarriers and thus improve and broaden usage of TiO2 nanoparticles in nanomedicine.
公开日期	2017-12-25
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/13674]
专题	2017专题
推荐引用方式 GB/T 7714	Ren, Wenzhi,Iqbal, M. Zubair,Zeng, Leyong,et al. Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer[J]. NANOSCALE,2017,9(31):11195-11204.
APA	Ren, Wenzhi.,Iqbal, M. Zubair.,Zeng, Leyong.,Chen, Tianxiang.,Pan, Yuanwei.,...&Wu, Aiguo.(2017).Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer.NANOSCALE,9(31),11195-11204.
MLA	Ren, Wenzhi,et al."Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer".NANOSCALE 9.31(2017):11195-11204.