Room-temperature deposition of hydroxyapatite/antibiotic composite coatings by vacuum cold spraying for antibacterial applications

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2017专题

	Room-temperature deposition of hydroxyapatite/antibiotic composite coatings by vacuum cold spraying for antibacterial applications
	Jin, Peipeng; Li, Deyan; Gong, Yongfeng; Chen, Xiuyong; Zhan, Botao; Zhang, Haijun; Li, Hua
刊名	SURFACE & COATINGS TECHNOLOGY
	2017
卷号	330 页码:87-91
ISSN号	0257-8972
英文摘要	To develop implants with long-term antibacterial property, hydroxyapatite (HA)-gentamicin sulfate (GS) composite powder were synthesized and deposited onto titanium substrates by vacuum cold spraying at room temperature. The successful fabrication of the HA-GS composite powder and coatings was confirmed by transmission electron microscopy (TEM), field-emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analysis, respectively. Gentamicin release kinetics, antibacterial property and biocompatibility were systematically investigated in vitro. Results indicate that we can effectively load the coating with antibiotic and the coating shows long-term antibacterial capacity. Moreover, the HA-GS composite coatings displayed excellent biocompatibility. The approach in this study provides an alternative to fabricate an efficient bioactive drug delivery system for biomedical applications.
公开日期	2017-12-25
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/13491]
专题	2017专题
推荐引用方式 GB/T 7714	Jin, Peipeng,Li, Deyan,Gong, Yongfeng,et al. Room-temperature deposition of hydroxyapatite/antibiotic composite coatings by vacuum cold spraying for antibacterial applications[J]. SURFACE & COATINGS TECHNOLOGY,2017,330:87-91.
APA	Jin, Peipeng.,Li, Deyan.,Gong, Yongfeng.,Chen, Xiuyong.,Zhan, Botao.,...&Li, Hua.(2017).Room-temperature deposition of hydroxyapatite/antibiotic composite coatings by vacuum cold spraying for antibacterial applications.SURFACE & COATINGS TECHNOLOGY,330,87-91.
MLA	Jin, Peipeng,et al."Room-temperature deposition of hydroxyapatite/antibiotic composite coatings by vacuum cold spraying for antibacterial applications".SURFACE & COATINGS TECHNOLOGY 330(2017):87-91.