Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination | |
Xia, Yufei1,2; Wu, Jie1,3; Wei, Wei1; Du, Yiqun1; Wan, Tao4,5; Ma, Xiaowei6; An, Wenqi6; Guo, Aiying6; Miao, Chunyu1; Yue, Hua1 | |
刊名 | NATURE MATERIALS |
2018-02-01 | |
卷号 | 17期号:2页码:187-+ |
ISSN号 | 1476-1122 |
DOI | 10.1038/NMAT5057 |
文献子类 | Article |
英文摘要 | A major challenge in vaccine formulations is the stimulation of both the humoral and cellular immune response for well-defined antigens with high efficacy and safety. Adjuvant research has focused on developing particulate carriers to model the sizes, shapes and compositions of microbes or diseased cells, but not antigen fluidity and pliability. Here, we develop Pickering emulsions-that is, particle-stabilized emulsions that retain the force-dependent deformability and lateral mobility of presented antigens while displaying high biosafety and antigen-loading capabilities. Compared with solid particles and conventional surfactant-stabilized emulsions, the optimized Pickering emulsions enhance the recruitment, antigen uptake and activation of antigen-presenting cells, potently stimulating both humoral and cellular adaptive responses, and thus increasing the survival of mice upon lethal challenge. The pliability and lateral mobility of antigen-loaded Pickering emulsions may provide a facile, effective, safe and broadly applicable strategy to enhance adaptive immunity against infections and diseases. |
WOS关键词 | T-cell-activation ; Immune-responses ; Cancer ; Vaccines ; Antigen ; Adjuvants ; Delivery ; Nanoparticles ; Phagocytosis ; Persistence |
WOS研究方向 | Chemistry ; Materials Science ; Physics |
语种 | 英语 |
WOS记录号 | WOS:000423153800019 |
资助机构 | National Science and Technology Major Project(2014ZX09102045) ; National Natural Science Foundation of China(21576268) |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/24089] |
专题 | 过程工程研究所_生化工程国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China 4.Second Mil Med Univ, State Key Lab Med Immunol, Shanghai 200433, Peoples R China 5.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China 6.Hualan Biol Bacterin Co Ltd, Xinxiang 453003, Peoples R China 7.Chinese Acad Sci, Inst Biophys, Ctr Biol Imaging, Beijing 100101, Peoples R China 8.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Yufei,Wu, Jie,Wei, Wei,et al. Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination[J]. NATURE MATERIALS,2018,17(2):187-+. |
APA | Xia, Yufei.,Wu, Jie.,Wei, Wei.,Du, Yiqun.,Wan, Tao.,...&Ma, Guanghui.(2018).Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination.NATURE MATERIALS,17(2),187-+. |
MLA | Xia, Yufei,et al."Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination".NATURE MATERIALS 17.2(2018):187-+. |
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