Cobalt-catalyzed intermolecular hydroacylation of aldehydes: initiation of hydride transfer enables turnover

doi:10.1039/c8qo00337h

	Cobalt-catalyzed intermolecular hydroacylation of aldehydes: initiation of hydride transfer enables turnover
	Li, Ting 1,2; Xu, Bao-Hua 1,2; Zhu, De-Ping 1,2; Wang, Yao-Feng 1; Zhang, Suo-Jiang 1,2
刊名	ORGANIC CHEMISTRY FRONTIERS
	2018-06-21
卷号	5 期号:12 页码:1933-1939
ISSN号	2052-4129
DOI	10.1039/c8qo00337h
英文摘要	Intermolecular hydroacylation of aldehydes catalyzed by an in situ generated low-valent cobalt system was developed. Mechanistic studies disclosed that the desired hydroacylation was impeded by poor hydride donation by the respective Co(III)-H phosphine complex formed by the oxidative addition of Co(I) to the formyl C-H bond. Surprisingly, the reaction rate was significantly promoted in the presence of Lewis base N,N-diisopropylethylamine (iPr(2)NEt) functioning as an initiator of hydride transfer, thereby offering an excellent reaction efficiency with high substrate tolerance.
资助项目	973 Program[2015CB251401] ; National Natural Science Foundation of China (Petrochemical Joint Fund)[U1662133] ; National Natural Science Foundation of China (Petrochemical Joint Fund)[21476240] ; Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-JSC011] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201521] ; State Key Laboratory of Multiphase Complex Systems, IPE, CAS[MPCS-2015-A-05] ; CAS 100-Talent Program
WOS关键词	C-H FUNCTIONALIZATION ; INTRAMOLECULAR HYDROACYLATION ; ALKYNE HYDROACYLATION ; AROMATIC-ALDEHYDES ; HOMOGENEOUS CATALYSIS ; ALKENES ; ACTIVATION ; MECHANISM ; OLEFINS ; COMPLEXES
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000435115200010
资助机构	973 Program ; National Natural Science Foundation of China (Petrochemical Joint Fund) ; Key Research Program of Frontier Sciences, CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; State Key Laboratory of Multiphase Complex Systems, IPE, CAS ; CAS 100-Talent Program
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/24893]
专题	中国科学院过程工程研究所
通讯作者	Xu, Bao-Hua; Zhang, Suo-Jiang
作者单位	1.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, State Key Lab Multiphase Complex Syst, Key Lab Green Proc & Engn,Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Ting,Xu, Bao-Hua,Zhu, De-Ping,et al. Cobalt-catalyzed intermolecular hydroacylation of aldehydes: initiation of hydride transfer enables turnover[J]. ORGANIC CHEMISTRY FRONTIERS,2018,5(12):1933-1939.
APA	Li, Ting,Xu, Bao-Hua,Zhu, De-Ping,Wang, Yao-Feng,&Zhang, Suo-Jiang.(2018).Cobalt-catalyzed intermolecular hydroacylation of aldehydes: initiation of hydride transfer enables turnover.ORGANIC CHEMISTRY FRONTIERS,5(12),1933-1939.
MLA	Li, Ting,et al."Cobalt-catalyzed intermolecular hydroacylation of aldehydes: initiation of hydride transfer enables turnover".ORGANIC CHEMISTRY FRONTIERS 5.12(2018):1933-1939.