Human adaptation and population differentiation in the light of ancient genomes

doi:10.1038/ncomms10775

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	Human adaptation and population differentiation in the light of ancient genomes
	Key, Felix M.1; Fu, Qiaomei 1,2,3; Romagne, Frederic 1; Lachmann, Michael 1,4; Andres, Aida M.1
刊名	NATURE COMMUNICATIONS
	2016-03-01
卷号	7
DOI	10.1038/ncomms10775
文献子类	Article
英文摘要	The influence of positive selection sweeps in human evolution is increasingly debated, although our ability to detect them is hampered by inherent uncertainties in the timing of past events. Ancient genomes provide snapshots of allele frequencies in the past and can help address this question. We combine modern and ancient genomic data in a simple statistic (DAnc) to time allele frequency changes, and investigate the role of drift and adaptation in population differentiation. Only 30% of the most strongly differentiated alleles between Africans and Eurasians changed in frequency during the colonization of Eurasia, but in Europe these alleles are enriched in genic and putatively functional alleles to an extent only compatible with local adaptation. Adaptive alleles-especially those associated with pigmentation-are mostly of hunter-gatherer origin, although lactose persistence arose in a haplotype present in farmers. These results provide evidence for a role of local adaptation in human population differentiation.
WOS关键词	RECENT POSITIVE SELECTION ; NATURAL-SELECTION ; POLYGENIC ADAPTATION ; GENETIC-VARIATION ; MUTATION-RATE ; EYE COLOR ; PIGMENTATION ; EUROPE ; SEQUENCE ; FARMERS
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000372407400001
资助机构	Max Planck Society ; Special Foundation of the President of the Chinese Academy of Sciences ; John Templeton Foundation
内容类型	期刊论文
源URL	[http://124.16.247.212/handle/311034/7125]
专题	古脊椎动物与古人类研究所_图书馆1
作者单位	1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Chinese Acad Sci, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 3.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 4.Santa Fe Inst, Santa Fe, NM 87501 USA
推荐引用方式 GB/T 7714	Key, Felix M.,Fu, Qiaomei,Romagne, Frederic,et al. Human adaptation and population differentiation in the light of ancient genomes[J]. NATURE COMMUNICATIONS,2016,7.
APA	Key, Felix M.,Fu, Qiaomei,Romagne, Frederic,Lachmann, Michael,&Andres, Aida M..(2016).Human adaptation and population differentiation in the light of ancient genomes.NATURE COMMUNICATIONS,7.
MLA	Key, Felix M.,et al."Human adaptation and population differentiation in the light of ancient genomes".NATURE COMMUNICATIONS 7(2016).