Interactions between amyloid beta peptide and lipid membranes

doi:10.1016/j.bbamem.2018.04.004

	Interactions between amyloid beta peptide and lipid membranes
	Niu, Zheng 1,2; Zhang, Zhengfeng 1; Zhao, Weijing 1; Yang, Jun 1
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
	2018-09-01
卷号	1860 期号:9 页码:1663-1669
关键词	Alzheimer's Disease Beta-amyloid Peptide Fibrillation Phospholipids Membrane Disruption Solid-state Nuclear Magnetic Resonance
ISSN号	0005-2736
DOI	10.1016/j.bbamem.2018.04.004
文献子类	Review
英文摘要	The presence of amyloid plaques in the brain is a typical characteristic of Alzheimer's disease (AD). Amyloid plaques are formed from the deposits of aggregated amyloid beta peptide (A beta). The toxicity induced by A beta aggregates is correlated with A beta-membrane interactions. The mutual influences between aggregation and membranes are complicated and unclear. In recent years advanced experiments and findings are emerging to give us more detailed information on A beta-membrane interactions. In this review, we mainly focus on the A beta-membrane interactions and membrane-induced A beta structures. The mechanism of A beta-membrane interactions is also summarized, which provides insights into the prevention and treatment of AD.
WOS关键词	ALZHEIMERS-DISEASE ; A-BETA ; METAL-IONS ; GANGLIOSIDE CLUSTERS ; SECONDARY NUCLEATION ; PROTEIN AGGREGATION ; MECHANISTIC INSIGHT ; MOLECULAR-STRUCTURE ; CHANNEL FORMATION ; FIBRIL FORMATION
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000442333600008
资助机构	National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803) ; National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803) ; National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803) ; National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/13040]
专题	中国科学院武汉物理与数学研究所
通讯作者	Yang, Jun
作者单位	1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 2.Tech Univ Munich, Dept Chem, D-85748 Garching, Germany
推荐引用方式 GB/T 7714	Niu, Zheng,Zhang, Zhengfeng,Zhao, Weijing,et al. Interactions between amyloid beta peptide and lipid membranes[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2018,1860(9):1663-1669.
APA	Niu, Zheng,Zhang, Zhengfeng,Zhao, Weijing,&Yang, Jun.(2018).Interactions between amyloid beta peptide and lipid membranes.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1860(9),1663-1669.
MLA	Niu, Zheng,et al."Interactions between amyloid beta peptide and lipid membranes".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1860.9(2018):1663-1669.