A F-19 NMR probe for the detection of beta-galactosidase: simple structure with low molecular weight of 274.2, "turn-on'' signal without the background, and good performance applicable in cancer cell line

doi:10.1039/c7tb00616k

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	A F-19 NMR probe for the detection of beta-galactosidase: simple structure with low molecular weight of 274.2, "turn-on'' signal without the background, and good performance applicable in cancer cell line
	Xie, Yujun 1; Li, Zhen 1; Li, Conggang 2; Cheng, Kai 2; Wu, Qiong 2; Hu, Jie 1
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2017-06-28
卷号	5 期号:24 页码:4673-4678
DOI	10.1039/c7tb00616k
文献子类	Article
英文摘要	Based on the efficient cleavage reaction of the C-O ether bond triggered by beta-gal selectively, FB-beta Gal, with good water-solubility, low toxicity, high specificity, excellent water-solubility and high biocompatibility, was prepared, which could report the presence of trace beta-gal quickly and conveniently by a significant change in the F-19 NMR spectra without any background noise. The successful application of FB-beta Gal for the detection of beta-gal in living Escherichia coli, HeLa cells and OVCAR-3 cells quantitatively makes it a promising candidate for practical application in related fields.
WOS关键词	GENE REPORTER MOLECULES ; TUMORS IN-VIVO ; OVARIAN-CANCER ; MAGNETIC-RESONANCE ; LIVING CELLS ; MRI ; VISUALIZATION ; GROWTH
WOS研究方向	Materials Science
语种	英语
WOS记录号	WOS:000404070600013
资助机构	National Science Foundation of China(21325416 ; National Science Foundation of China(21325416 ; Ministry of Science and Technology of China(2013CB910202) ; Ministry of Science and Technology of China(2013CB910202) ; 215755156) ; 215755156) ; National Science Foundation of China(21325416 ; National Science Foundation of China(21325416 ; Ministry of Science and Technology of China(2013CB910202) ; Ministry of Science and Technology of China(2013CB910202) ; 215755156) ; 215755156)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/11483]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Wuhan Univ, Dept Chem, Hubei Key Lab Organ & Polymer Optoelect Mat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, China State Key Lab Magnet Resonance & Atom & Mol, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Xie, Yujun,Li, Zhen,Li, Conggang,et al. A F-19 NMR probe for the detection of beta-galactosidase: simple structure with low molecular weight of 274.2, "turn-on'' signal without the background, and good performance applicable in cancer cell line[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(24):4673-4678.
APA	Xie, Yujun,Li, Zhen,Li, Conggang,Cheng, Kai,Wu, Qiong,&Hu, Jie.(2017).A F-19 NMR probe for the detection of beta-galactosidase: simple structure with low molecular weight of 274.2, "turn-on'' signal without the background, and good performance applicable in cancer cell line.JOURNAL OF MATERIALS CHEMISTRY B,5(24),4673-4678.
MLA	Xie, Yujun,et al."A F-19 NMR probe for the detection of beta-galactosidase: simple structure with low molecular weight of 274.2, "turn-on'' signal without the background, and good performance applicable in cancer cell line".JOURNAL OF MATERIALS CHEMISTRY B 5.24(2017):4673-4678.