Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China

doi:10.1136/thoraxjnl-2016-208910

CORC > 地球环境研究所 > 中国科学院地球环境研究所 > 粉尘与环境研究室

	Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China
	Li,XC(Li,Xiaochen)3; Zhao,DX(Zhao,Dongxing)3; Zou,WF(Zou,Weifeng)6; Chen,XY(Chen,Xinyu)5; Liu,SX(Liu,Suixin)4; Zhou,YM(Zhou,Yumin)3; Liu,S(Liu,Sha)3; Ran,Pixin ; Ran,PX(Ran,Pixin)3; Liu,SL(Liu,Shiliang)1,2
刊名	Chronic obstructive pulmonary disease
	2017-09
卷号	72 期号:9 页码:788-795
关键词	Copd Epidemiology
DOI	10.1136/thoraxjnl-2016-208910
文献子类	期刊论文
英文摘要	Objective The association between exposure to ambient particles with a median aerodynamic diameter less than 10/2.5 µm (particulate matter, PM10/2.5) and COPD remains unclear. Our study objective was to examine the association between ambient PM10/2.5 concentrations and lung functions in adults. Methods A cross-sectional study was conducted in southern China. Seven clusters were randomly selected from four cities across Guangdong province. Residents aged ≥20 years in the participating clusters were randomly recruited; all eligible participants were examined with a standardised questionnaire and spirometry. COPD was defined as a post-bronchodilator FEV1/FVC less than 70%. Atmosphere PM sampling was conducted across the clusters along with our survey. Results Of the subjects initially recruited, 84.4% (n=5993) were included for analysis. COPD prevalence and atmosphere PM concentration varied significantly among the seven clusters. COPD prevalence was significantly associated with elevated PM concentration levels: adjusted OR 2.416 (95% CI 1.417 to 4.118) for >35 and ≤75 µg/m3 and 2.530 (1.280 to 5.001) for >75 µg/m3 compared with the level of ≤35 µg/m3 for PM2.5; adjusted OR 2.442 (95% CI 1.449 to 4.117) for >50 and ≤150 µg/m3 compared with the level of ≤50 µg/m3 for PM1. A 10 µg/m3 increase in PM2.5 concentrations was associated with a 26 mL (95% CI −43 to −9) decrease in FEV1, a 28 mL (−49 to −8) decrease in FVC and a 0.09% decrease (−0.170 to −0.010) in FEV1/FVC ratio. The associations of COPD with PM10 were consistent with PM2.5 but slightly weaker. Conclusions Exposure to higher PM concentrations was strongly associated with increased COPD prevalence and declined respiratory function.
项目编号	2012BAI05B01 ; 81170043 ; 81470233 ; 20l5CB553403
语种	英语
资助机构	Chinese central government key researchprojects of the 12th national five-year development plan ; Chinese central government key researchprojects of the 12th national five-year development plan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Basic Research and Development Programme,973 Program ; National Key Basic Research and Development Programme,973 Program
内容类型	期刊论文
源URL	[http://ir.ieecas.cn/handle/361006/5574]
专题	地球环境研究所_粉尘与环境研究室
通讯作者	Ran,Pixin
作者单位	1.The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China 2.School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa ON, Canada 3.The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China 4.Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, China 5.Department of Pathogenic Biology, Guangzhou Medical University, Guangzhou, China 6.Guangzhou Chest Hospital, Guangzhou, Guangdong, China 7.The Research Center of Experimental Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China
推荐引用方式 GB/T 7714	Li,XC,Zhao,DX,Zou,WF,et al. Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China[J]. Chronic obstructive pulmonary disease,2017,72(9):788-795.
APA	Li,XC.,Zhao,DX.,Zou,WF.,Chen,XY.,Liu,SX.,...&Pu,JD.(2017).Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China.Chronic obstructive pulmonary disease,72(9),788-795.
MLA	Li,XC,et al."Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China".Chronic obstructive pulmonary disease 72.9(2017):788-795.