Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus

doi:10.1016/j.phytochem.2017.01.006

	Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus
	Yu, K; Wang, MK (reprint author), Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China.; Wang, MK; Liu, X; Khan, AA; Li, F; Zhang, WM; Jiang, XL; Wang, L
刊名	PHYTOCHEMISTRY
	2017
卷号	136 期号:2017 页码:125-132
关键词	Ophiopogon Japonicus Liliaceae C-29-steroidal Saponins C-27-steroidal Saponins Cytotoxic Activity
DOI	10.1016/j.phytochem.2017.01.006
产权排序	2
文献子类	Article
英文摘要	Phytochemical investigation of the tubers of Ophiopogon japonicus led to the isolation of five previously undescribed steroidal saponins, ophiojaponins A-E, together with twelve known ones. The structures of these isolated compounds were elucidated by detailed spectroscopic analyses and chemical methods. Ophiojaponins A-C are rare naturally occurring C-29 steroidal glycosides possessing a homo-cholestane skeleton with an aromatized ring E. Ruscogenin 1-O-alpha-L-rhamnopyranosyl-(1 -> 2)-4-O-sulfo-(beta-Dfucopyranosido-3-O-beta-D-glucopyranoside was isolated as single component and its full spectroscopic data was reported for the first time. The isolated steroidal saponins were evaluated for their cytotoxicities against two human tumor cell lines MG-63 and SNU387. Among them, five known spirostane-type glycosides showed cytotoxic activity against both MG-63 and SNU387 cell lines with IC50 values ranging from 0.76 to 27.0 M. (C) 2017 Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
资助机构	We are very grateful to the Key Research Program of the Chinese Academy of Sciences, Grant No. KSZD-EW-Z-004 and the National Natural Science Foundation of China (No. 21561142003) for financial support. ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; We are very grateful to the Key Research Program of the Chinese Academy of Sciences, Grant No. KSZD-EW-Z-004 and the National Natural Science Foundation of China (No. 21561142003) for financial support. ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003] ; We are very grateful to the Key Research Program of the Chinese Academy of Sciences, Grant No. KSZD-EW-Z-004 and the National Natural Science Foundation of China (No. 21561142003) for financial support. ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; We are very grateful to the Key Research Program of the Chinese Academy of Sciences, Grant No. KSZD-EW-Z-004 and the National Natural Science Foundation of China (No. 21561142003) for financial support. ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/29249]
专题	成都生物研究所_天然产物研究
通讯作者	Wang, MK (reprint author), Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China.; Li, F
推荐引用方式 GB/T 7714	Yu, K,Wang, MK ,Wang, MK,et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus[J]. PHYTOCHEMISTRY,2017,136(2017):125-132.
APA	Yu, K.,Wang, MK .,Wang, MK.,Liu, X.,Khan, AA.,...&Wang, L.(2017).Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus.PHYTOCHEMISTRY,136(2017),125-132.
MLA	Yu, K,et al."Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus".PHYTOCHEMISTRY 136.2017(2017):125-132.