Isolation, identification and characterization of potential impurities of anidulafungin

doi:10.1016/j.jpba.2017.04.014

	Isolation, identification and characterization of potential impurities of anidulafungin
	Zhao, LN; Wang, QL; Bie, Y; Lu, XX; Lu, XX (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
刊名	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
	2017
卷号	141 期号:2017 页码:192-199
关键词	Anidulafungin Impurities Isolation Identification Structure Elucidation
DOI	10.1016/j.jpba.2017.04.014
产权排序	1
文献子类	Article
英文摘要	Eight impurities ranging from 0.03 to 0.97% in anidulafungin bulk drug were detected by HPLC. Four impurities (Imp-I, Imp-II, Imp-III and Imp-VIII) among impurities were isolated from the self-prepared or marketed samples of anidulafungin bulk drug by means of preparative HPLC. A thorough study was undertaken to characterize these impurities and based on 1D (H-1, C-13, H-D, DEPT 90 and 135) and 2D (COSY, TOCSY, HSQC, HMBC) NMR and ESI-MS spectral data. Based on the characterization data, Imp-I was found to be known open-chain hydrolysis product formed during the synthesis and degradation. Imp-II and Imp-III was lacked a methyl group at the C-4 and C-8 in anidulafungin, respectively, whereas Imp-VIII contained a methoxy group at the C-23. The latter three new impurities were identified as process-related substances. (C) 2017 Elsevier B.V. All rights reserved.
学科主题	Chemistry ; Pharmacology & Pharmacy
语种	英语
资助机构	This work was partly supported by National Science Foundation of China (No. 21272229) and Science and Technology Service Network Initiative of Chinese Academy of Sciences (No. KFJ-SW-STS-143-1). ; National Science Foundation of China [21272229] ; This work was partly supported by National Science Foundation of China (No. 21272229) and Science and Technology Service Network Initiative of Chinese Academy of Sciences (No. KFJ-SW-STS-143-1). ; National Science Foundation of China [21272229] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences [KFJ-SW-STS-143-1] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences [KFJ-SW-STS-143-1] ; This work was partly supported by National Science Foundation of China (No. 21272229) and Science and Technology Service Network Initiative of Chinese Academy of Sciences (No. KFJ-SW-STS-143-1). ; National Science Foundation of China [21272229] ; This work was partly supported by National Science Foundation of China (No. 21272229) and Science and Technology Service Network Initiative of Chinese Academy of Sciences (No. KFJ-SW-STS-143-1). ; National Science Foundation of China [21272229] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences [KFJ-SW-STS-143-1] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences [KFJ-SW-STS-143-1]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/29224]
专题	成都生物研究所_天然产物研究
通讯作者	Lu, XX (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
推荐引用方式 GB/T 7714	Zhao, LN,Wang, QL,Bie, Y,et al. Isolation, identification and characterization of potential impurities of anidulafungin[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017,141(2017):192-199.
APA	Zhao, LN,Wang, QL,Bie, Y,Lu, XX,&Lu, XX .(2017).Isolation, identification and characterization of potential impurities of anidulafungin.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,141(2017),192-199.
MLA	Zhao, LN,et al."Isolation, identification and characterization of potential impurities of anidulafungin".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 141.2017(2017):192-199.