Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch | |
Yuan, Y; Zhao, YY; Chen, LQ; Wu, JS; Chen, GY; Li, S; Zou, JW; Chen, R; Wang, J; Jiang, F | |
刊名 | NUCLEIC ACIDS RESEARCH
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2017 | |
卷号 | 45期号:15页码:8676-8683 |
DOI | 10.1093/nar/gkx602 |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | Riboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce singlestrand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the photo-irradiation could induce the death of tumor cells that are defective in mismatch repair system selectively, highlighting the G-T mismatch as potential drug target for tumor cells. Moreover, riboflavin is a promising leading compound for further drug design due to its inherent specific recognition of the G-T mismatch. |
学科主题 | Biochemistry & Molecular Biology |
语种 | 英语 |
资助机构 | Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; National Sciences Foundation of China [21322208, 21572222] ; National Sciences Foundation of China [21322208, 21572222] ; Innovative Team of Sichuan Province [2017TD0021] ; Innovative Team of Sichuan Province [2017TD0021] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; National Sciences Foundation of China [21322208, 21572222] ; National Sciences Foundation of China [21322208, 21572222] ; Innovative Team of Sichuan Province [2017TD0021] ; Innovative Team of Sichuan Province [2017TD0021] |
内容类型 | 期刊论文 |
源URL | [http://210.75.237.14/handle/351003/29213] ![]() |
专题 | 成都生物研究所_天然产物研究 |
通讯作者 | Tang, Z (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China.; Wang, J (reprint author), Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Sichuan, Peoples R China.; Jiang, F (reprint author), Peking Univ, Lab Computat Chem & Drug Design, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China. |
推荐引用方式 GB/T 7714 | Yuan, Y,Zhao, YY,Chen, LQ,et al. Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch[J]. NUCLEIC ACIDS RESEARCH,2017,45(15):8676-8683. |
APA | Yuan, Y.,Zhao, YY.,Chen, LQ.,Wu, JS.,Chen, GY.,...&Jiang, F .(2017).Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch.NUCLEIC ACIDS RESEARCH,45(15),8676-8683. |
MLA | Yuan, Y,et al."Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch".NUCLEIC ACIDS RESEARCH 45.15(2017):8676-8683. |
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