Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch

doi:10.1093/nar/gkx602

	Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch
	Yuan, Y; Zhao, YY; Chen, LQ; Wu, JS; Chen, GY; Li, S; Zou, JW; Chen, R; Wang, J; Jiang, F
刊名	NUCLEIC ACIDS RESEARCH
	2017
卷号	45 期号:15 页码:8676-8683
DOI	10.1093/nar/gkx602
产权排序	1
文献子类	Article
英文摘要	Riboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce singlestrand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the photo-irradiation could induce the death of tumor cells that are defective in mismatch repair system selectively, highlighting the G-T mismatch as potential drug target for tumor cells. Moreover, riboflavin is a promising leading compound for further drug design due to its inherent specific recognition of the G-T mismatch.
学科主题	Biochemistry & Molecular Biology
语种	英语
资助机构	Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; National Sciences Foundation of China [21322208, 21572222] ; National Sciences Foundation of China [21322208, 21572222] ; Innovative Team of Sichuan Province [2017TD0021] ; Innovative Team of Sichuan Province [2017TD0021] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]; National Sciences Foundation of China [21322208, 21572222]; The Innovative Team of Sichuan Province [2017TD0021]. ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029] ; National Sciences Foundation of China [21322208, 21572222] ; National Sciences Foundation of China [21322208, 21572222] ; Innovative Team of Sichuan Province [2017TD0021] ; Innovative Team of Sichuan Province [2017TD0021]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/29213]
专题	成都生物研究所_天然产物研究
通讯作者	Tang, Z (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China.; Wang, J (reprint author), Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Sichuan, Peoples R China.; Jiang, F (reprint author), Peking Univ, Lab Computat Chem & Drug Design, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China.
推荐引用方式 GB/T 7714	Yuan, Y,Zhao, YY,Chen, LQ,et al. Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch[J]. NUCLEIC ACIDS RESEARCH,2017,45(15):8676-8683.
APA	Yuan, Y.,Zhao, YY.,Chen, LQ.,Wu, JS.,Chen, GY.,...&Jiang, F .(2017).Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch.NUCLEIC ACIDS RESEARCH,45(15),8676-8683.
MLA	Yuan, Y,et al."Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch".NUCLEIC ACIDS RESEARCH 45.15(2017):8676-8683.