Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata

doi:10.1186/s13065-016-0172-1

	Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata
	Tang, L; Yin, L; Lu, QX; Tan, SC; Ding, LS; Guo, YR; Chen, F; Tang, L (reprint author), Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, 24 South Sect 1,Yihuan Rd, Chengdu, Peoples R China.
刊名	CHEMISTRY CENTRAL JOURNAL
	2016
卷号	10 页码:27（1-8）
关键词	Scrophulariaceae Veronica Ciliata Antioxidant Anti-hepatocarcinoma Iridoid Glycosides Bioactivity-guided Screening
DOI	10.1186/s13065-016-0172-1
产权排序	3
文献子类	Article
英文摘要	Background: Veronica ciliata Fisch., widely distributed in western China, has been traditionally used in Tibetan Medicine as a treatment for hepatitis, cholecystitis, rheumatism, and urticaria. However, V. ciliata Fisch. has not been subjected to detailed chemical constitution analysis and the bioactive studies were restricted to its crude extracts. It is necessary to investigate the active chemical components of these extracts and identify their biological effects. Results: Four iridoid glycosides, (veronicoside, cataposide, amphicoside, and verminoside) were isolated from the ethyl acetate fraction. Among these compounds, veronicoside and verminoside were isolated for the first time from this plant. These compounds exhibited strong antioxidant activity and inhibitory activity on HepG2 cell proliferation. The antioxidant activity of verminoside was equal to Vc. Cataposide, amphicoside and verminoside had stronger anti-hepatocarcinoma activity than 5-fluorouracil. Conclusions: Four iridoid glycosides, (veronicoside, cataposide, amphicoside and verminoside) were isolated from the extract of V. ciliata Fisch. using bioassay-guided screening. Among these compounds, veronicoside and verminoside were isolated for the first time from this plant. The above results indicated that these compounds were the active chemical components responsible for the antioxidant and anti-hepatocarcinoma properties of V. ciliata Fisch. The underlying mechanism of their bioactivity is worthy of further investigation.
学科主题	Chemistry
资助项目	中国科学院山地生态恢复与生物资源利用重点实验室
语种	英语
资助机构	National Natural Science Foundation of China [31570351] ; National Natural Science Foundation of China [31570351] ; National Natural Science Foundation of China [31570351] ; National Natural Science Foundation of China [31570351]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/28195]
专题	成都生物研究所_天然产物研究
通讯作者	Tang, L (reprint author), Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, 24 South Sect 1,Yihuan Rd, Chengdu, Peoples R China.
推荐引用方式 GB/T 7714	Tang, L,Yin, L,Lu, QX,et al. Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata[J]. CHEMISTRY CENTRAL JOURNAL,2016,10:27（1-8）.
APA	Tang, L.,Yin, L.,Lu, QX.,Tan, SC.,Ding, LS.,...&Tang, L .(2016).Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata.CHEMISTRY CENTRAL JOURNAL,10,27（1-8）.
MLA	Tang, L,et al."Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata".CHEMISTRY CENTRAL JOURNAL 10(2016):27（1-8）.