Porous Iron-Carboxylate Metal-Organic Framework: A Novel Bioplatform with Sustained Antibacterial Efficacy and Nontoxicity.

	Porous Iron-Carboxylate Metal-Organic Framework: A Novel Bioplatform with Sustained Antibacterial Efficacy and Nontoxicity.
	Lin, Sha; Liu, Xiangmei; Tan, Lei; Cui, Zhenduo; Yang, Xianjin; Yeung, Kelvin W. K.; Pan, Haobo; Wu, Shuilin
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
文献子类	期刊论文
英文摘要	Sustained drug release plays a critical role in targeting the therapy of local diseases such as bacterial infections. In the present work, porous iron-carboxylatemetal-organic framework [MOF-53(Fe)] nanoparticles (NPs) were designed to entrap the vancomycin (Van) drugs. This system exhibited excellent chemical stability under acidic conditions (pH 7.4, 6.5, and 5.5) and much higher drug-loading capability because of the high porosity and large surface area of MOF NPs. The results showed that the drug-loading ratio of Van could reach 20 wt % and that the antibacterial ratio of the MOF-53(Fe)/Van system against Staphylococcus aureus could reach up to 90%. In addition, this MOF-53(Fe)/Van system exhibited excellent biocompatibility because of its chemical stability and sustained release of iron ions. Hence, these porous MOF NPs are a promising bioplatform not only for local therapy of bacterial infections but also for other biomedical therapies for tissue regeneration.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12362]
专题	深圳先进技术研究院_医药所
作者单位	ACS APPLIED MATERIALS & INTERFACES
推荐引用方式 GB/T 7714	Lin, Sha,Liu, Xiangmei,Tan, Lei,et al. Porous Iron-Carboxylate Metal-Organic Framework: A Novel Bioplatform with Sustained Antibacterial Efficacy and Nontoxicity.[J]. ACS APPLIED MATERIALS & INTERFACES,2017.
APA	Lin, Sha.,Liu, Xiangmei.,Tan, Lei.,Cui, Zhenduo.,Yang, Xianjin.,...&Wu, Shuilin.(2017).Porous Iron-Carboxylate Metal-Organic Framework: A Novel Bioplatform with Sustained Antibacterial Efficacy and Nontoxicity..ACS APPLIED MATERIALS & INTERFACES.
MLA	Lin, Sha,et al."Porous Iron-Carboxylate Metal-Organic Framework: A Novel Bioplatform with Sustained Antibacterial Efficacy and Nontoxicity.".ACS APPLIED MATERIALS & INTERFACES (2017).