Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy

	Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy
	Xi, Tingfei; Wong, Hoi Man; Zhao, Ying; Leung, Frankie K. L; Zhang, Zhixiong; Zheng, Yufeng; Wu, Shuilin; Wu, Shuilin
刊名	ADVANCED HEALTHCARE MATERIALS
	2017
文献子类	期刊论文
英文摘要	To achieve enhanced biological response and controlled degradation of magnesium alloy, a modified biodegradable polymer coating called polycaprolactone (PCL) is fabricated by a thermal approach in which the heat treatment neither alters the chemical composition of the PCL membrane nor the rate of magnesium ion release, pH value, or weight loss, compared with the untreated sample. The changes in the crystallinity, hydrophilicity, and oxygen content of heat-treated PCL coating not only improve the mechanical adhesion strength between the coating and magnesium substrate but also enhance the biological properties. Moreover, the thermally modified sample can lead to higher spreading and elongation of osteoblasts, due to the enhanced hydrophilicity and CO to CO functional group ratio. In the analyses of microcomputed tomography from one to four weeks postoperation, the total volume of new bone formation on the heat-treated sample is 10%–35% and 70%–90% higher than that of the untreated and uncoated controls, respectively. Surprisingly, the indentation modulus of the newly formed bone adjacent to the heat-treated sample is ≈20% higher than that of both controls. These promising results reveal the clinical potential of the modified PCL coating on magnesium alloy in orthopedic applications.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12357]
专题	深圳先进技术研究院_医药所
作者单位	ADVANCED HEALTHCARE MATERIALS
推荐引用方式 GB/T 7714	Xi, Tingfei,Wong, Hoi Man,Zhao, Ying,et al. Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy[J]. ADVANCED HEALTHCARE MATERIALS,2017.
APA	Xi, Tingfei.,Wong, Hoi Man.,Zhao, Ying.,Leung, Frankie K. L.,Zhang, Zhixiong.,...&Wu, Shuilin.(2017).Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy.ADVANCED HEALTHCARE MATERIALS.
MLA	Xi, Tingfei,et al."Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy".ADVANCED HEALTHCARE MATERIALS (2017).