Drug detoxification dynamics explain the postantibiotic effect.

	Drug detoxification dynamics explain the postantibiotic effect.
	Lopatkin, Allison J.; Srimani, Jaydeep K.; Huang, Shuqiang; You, Lingchong
刊名	MOLECULAR SYSTEMS BIOLOGY
	2017
文献子类	期刊论文
英文摘要	The postantibiotic effect (PAE) refers to the temporary suppression of bacterial growth following transient antibiotic treatment. This effect has been observed for decades for a wide variety of antibiotics and microbial species. However, despite empirical observations, a mechanistic understanding of this phenomenon is lacking. Using a combination of modeling and quantitative experiments, we show that the PAE can be explained by the temporal dynamics of drugdetoxification in individual cells after an antibiotic is removed from the extracellular environment. These dynamics are dictated by both the export of theantibiotic and the intracellular titration of the antibiotic by its target. This mechanism is generally applicable for antibiotics with different modes of action. We further show that efflux inhibition is effective against certain antibiotic motifs, which may help explain mixed cotreatment success.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12337]
专题	深圳先进技术研究院_医药所
作者单位	MOLECULAR SYSTEMS BIOLOGY
推荐引用方式 GB/T 7714	Lopatkin, Allison J.,Srimani, Jaydeep K.,Huang, Shuqiang,et al. Drug detoxification dynamics explain the postantibiotic effect.[J]. MOLECULAR SYSTEMS BIOLOGY,2017.
APA	Lopatkin, Allison J.,Srimani, Jaydeep K.,Huang, Shuqiang,&You, Lingchong.(2017).Drug detoxification dynamics explain the postantibiotic effect..MOLECULAR SYSTEMS BIOLOGY.
MLA	Lopatkin, Allison J.,et al."Drug detoxification dynamics explain the postantibiotic effect.".MOLECULAR SYSTEMS BIOLOGY (2017).