Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity. | |
Wang, Zai; Li, Yun-Xuan; Wang, Zhen-He; Gong, Huan; Lin, Ya-Jun; Pang, Jing; Cui, Ju; Huang, Jian-Dong; Jiang, Ping; Li, Jin | |
刊名 | FASEB JOURNAL |
2017 | |
文献子类 | 期刊论文 |
英文摘要 | Recent studies haveshownthatKIF5B (conventionalkinesin heavy chain) mediates glucose transporter type 4 translocation and adiponectin secretion in 3T3-L1 adipocytes, suggesting an involvement of KIF5B in the homeostasis of metabolism. However, the in vivo physiologic function ofKIF5B in adipose tissue remains to be determined. In this study, adipose-specific Kif5b knockout (F-K5bKO) mice were generated using the Cre-LoxP strategy. F-K5bKO mice had similar body weights to controls fed on a standard chow diet. However, F-K5bKO mice had hyperlipidemia and significant glucose intolerance and insulin resistance.Deletion of Kif5b aggravated the deleterious impact of a high-fat diet (HFD) on body weight gain, hepatosteatosis, glucose tolerance, and systematic insulinsensitivity. These changes were accompanied by impaired insulin signaling, decreased secretion of adiponectin, and increased serum levels of leptin and proinflammatory adipokines. F-K5bKO mice fed on an HFD exhibited lower energy expenditure and thermogenic dysfunction as a result of whitening of brown adipose due to decreased mitochondria biogenesis and down regulation of key thermogenicgene expression. In conclusion, selective deletion of Kif5b inadipose tissue exacerbates HFD-induced obesity and its associated metabolic disorders, partly through a decrease in energy expenditure, dysregulation ofadipokine secretion, and insulin signaling.-Cui, J., Pang, J., Lin, Y.-J., Gong, H., Wang, Z.-H., Li, Y.-X., Li, J., Wang, Z., Jiang, P., Dai, D.-P., Li, J., Cai, J.-P., Huang, J.-D., Zhang, T.-M. Adipose-specific deletionof Kif5b exacerbates obesity and insulin resistance in a mousemodel of diet-induced obesity. |
URL标识 | 查看原文 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.siat.ac.cn:8080/handle/172644/12327] |
专题 | 深圳先进技术研究院_医药所 |
作者单位 | FASEB JOURNAL |
推荐引用方式 GB/T 7714 | Wang, Zai,Li, Yun-Xuan,Wang, Zhen-He,et al. Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.[J]. FASEB JOURNAL,2017. |
APA | Wang, Zai.,Li, Yun-Xuan.,Wang, Zhen-He.,Gong, Huan.,Lin, Ya-Jun.,...&Dai, Da-Peng.(2017).Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity..FASEB JOURNAL. |
MLA | Wang, Zai,et al."Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.".FASEB JOURNAL (2017). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论