Fibril-Barrel Transitions in Cylindrin Amyloids.

	Fibril-Barrel Transitions in Cylindrin Amyloids.
	Xi, Wenhui ; Wei, Yanjie; Zhang, Huiling ; Hansmann, Ulrich H. E.
刊名	JOURNAL OF CHEMICAL THEORY AND COMPUTATION
	2017
文献子类	期刊论文
英文摘要	We introduce Replica-Exchange-with-Tunneling (RET) simulations as a tool for studies of the conversion between polymorphic amyloids. For the 11-residue amyloid-forming cylindrin peptide we show that this technique allows for a more efficient sampling of the formation and interconversion between fibril-like and barrel-like assemblies. We describe a protocol for optimized analysis of RET simulations that allows us to propose a mechanism for formation and interconversion between various cylindrin assemblies. Especially, we show that an interchain salt bridge between residues K3 and D7 is crucial for formation of the barrel structure.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12468]
专题	深圳先进技术研究院_数字所
作者单位	JOURNAL OF CHEMICAL THEORY AND COMPUTATION
推荐引用方式 GB/T 7714	Xi, Wenhui , Wei, Yanjie,Zhang, Huiling ,et al. Fibril-Barrel Transitions in Cylindrin Amyloids.[J]. JOURNAL OF CHEMICAL THEORY AND COMPUTATION,2017.
APA	Xi, Wenhui , Wei, Yanjie,Zhang, Huiling ,& Hansmann, Ulrich H. E. .(2017).Fibril-Barrel Transitions in Cylindrin Amyloids..JOURNAL OF CHEMICAL THEORY AND COMPUTATION.
MLA	Xi, Wenhui ,et al."Fibril-Barrel Transitions in Cylindrin Amyloids.".JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2017).