Nano artificial red cells with sufficient oxygen supply for boosted photodynamic therapy

	Nano artificial red cells with sufficient oxygen supply for boosted photodynamic therapy
	Luo, Zhenyu ; Zheng, Mingbin ; Zhao, Pengfei ; Chen, Ze ; Cai, Lintao
刊名	Journal of Controlled Release
	2017
文献子类	期刊论文
英文摘要	Photodynamic therapy (PDT) has been increasingly applied in clinical cancer treatments. However, native hypoxic tumor microenvironment and lacking of oxygen supply are major barriers to potent photodynamic reactions. Here, we report smart nano artificial red cells loading photosensitizer and hemoglobin with synchronous oxygen supply for boosted photodynamic strategy (Fig. 1). Protected by the lipid-polymer core-shell nanostructure, the interactive photosensitizer and hemoglobin showexcellent acidic/thermal stability. Upon exposure to near-infrared laser, the remote-detonated photosensitizer generates massive cytotoxic reactive oxygen species (ROS) with sufficient oxygen supply. Simultaneously, hemoglobin is oxidized into the more active ferryl-hemoglobin, which has a 35-fold half-autoreduction time than ROS, leading to rather prolonged cytotoxicity. ROS and ferrylhemoglobin synergistically trigger the oxidative damage of tumor resulting in complete suppression. Moreover, the photosensitizerloaded nano artificial red cells spontaneously act as an ideal fluorescent/photoacoustic (FL/PA) dual-modality imaging probe, dynamically monitoring the photosensitizer/oxygen metabolism and consumption, which could be served as a versatile theranostic platform.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12265]
专题	深圳先进技术研究院_医药所
作者单位	Journal of Controlled Release
推荐引用方式 GB/T 7714	Luo, Zhenyu , Zheng, Mingbin , Zhao, Pengfei ,et al. Nano artificial red cells with sufficient oxygen supply for boosted photodynamic therapy[J]. Journal of Controlled Release,2017.
APA	Luo, Zhenyu , Zheng, Mingbin , Zhao, Pengfei , Chen, Ze ,& Cai, Lintao.(2017).Nano artificial red cells with sufficient oxygen supply for boosted photodynamic therapy.Journal of Controlled Release.
MLA	Luo, Zhenyu ,et al."Nano artificial red cells with sufficient oxygen supply for boosted photodynamic therapy".Journal of Controlled Release (2017).