Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes

doi:10.1002/anie.201801498

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes
	Liu, P ; Zhao, Y ; Liu, XG ; Sun, JX ; Xu, DD ; Li, Y ; Li, Q ; Wang, LH ; Yang, SC ; Fan, CH
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2018
卷号	57 期号:19 页码:5418-5422
关键词	X-ray-scattering Origami Nanostructures Molecular-dynamics Crystal-structure Channel Membrane Transport Elasticity Mechanisms
ISSN号	1433-7851
DOI	10.1002/anie.201801498
文献子类	期刊论文
英文摘要	Reconfiguration of membrane protein channels for gated transport is highly regulated under physiological conditions. However, a mechanistic understanding of such channels remains challenging owing to the difficulty in probing subtle gating-associated structural changes. Herein, we show that charge neutralization can drive the shape reconfiguration of a biomimetic 6-helix bundle DNA nanotube (6HB). Specifically, 6HB adopts a compact state when its charge is neutralized by Mg2+; whereas Na+ switches it to the expanded state, as revealed by MD simulations, small-angle X-ray scattering (SAXS), and FRET characterization. Furthermore, partial neutralization of the DNA backbone charges by chemical modification renders 6HB compact and insensitive to ions, suggesting an interplay between electrostatic and hydrophobic forces in the channels. This system provides a platform for understanding the structure-function relationship of biological channels and designing rules for the shape control of DNA nanostructures in biomedical applications.
语种	英语
WOS记录号	WOS:000431035500041
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/28939]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Liu, P 2.Zhao, Y 3.Liu, XG 4.Sun, JX 5.Xu, DD 6.Li, Y 7.Li, Q 8.Wang, LH 9.Yang, SC 10.Fan, CH
推荐引用方式 GB/T 7714	Liu, P,Zhao, Y,Liu, XG,et al. Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(19):5418-5422.
APA	Liu, P.,Zhao, Y.,Liu, XG.,Sun, JX.,Xu, DD.,...&Lin, JP.(2018).Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(19),5418-5422.
MLA	Liu, P,et al."Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.19(2018):5418-5422.