(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

	(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats
	Li, Wan 1,2; Liu, Huihui 3; Jiang, Hanjie 1,2; Wang, Chen 1,2; Guo, Yongfei 1,2; Sun, Yi 1,2; Zhao, Xin 1,2; Xiong, Xin 4; Zhang, Xianhua 4; Zhang, Ke 1,2
刊名	SCIENTIFIC REPORTS
	2017-08-30
卷号	7
英文摘要	Chronic cerebral hypoperfusion is a pathological state that is associated with the cognitive impairments in vascular dementia. Oxiracetam is a nootropic drug that is commonly used to treat cognitive deficits of cerebrovascular origins. However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, we first identified that (S)-oxiracetam, but not (R)-oxiracetam, was the effective ingredient that alleviated the impairments of spatial learning and memory by ameliorating neuron damage and white matter lesions, increasing the cerebral blood flow, and inhibiting astrocyte activation in chronic cerebral hypoperfused rats. Furthermore, using MALD-IMSI and LC-MS/MS, we demonstrated that (S)-oxiracetam regulated ATP metabolism, glutamine-glutamate and anti-oxidants in the cortex region of hypoperfused rats. Altogether, our results strongly suggest that (S)-oxiracetam alone could be a nootropic drug for the treatment of cognitive impairments caused by cerebral hypoperfusion.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39282]
专题	化学研究所_活体分析化学实验室
作者单位	1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 4.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Li, Wan,Liu, Huihui,Jiang, Hanjie,et al. (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats[J]. SCIENTIFIC REPORTS,2017,7.
APA	Li, Wan.,Liu, Huihui.,Jiang, Hanjie.,Wang, Chen.,Guo, Yongfei.,...&Pu, Xiaoping.(2017).(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats.SCIENTIFIC REPORTS,7.
MLA	Li, Wan,et al."(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats".SCIENTIFIC REPORTS 7(2017).