In situ synthesis of bilayered gradient poly(vinyl alcohol)/hydroxyapatite composite hydrogel by directional freezing-thawing and electrophoresis method

	In situ synthesis of bilayered gradient poly(vinyl alcohol)/hydroxyapatite composite hydrogel by directional freezing-thawing and electrophoresis method
	Su, Cui 1,2; Su, Yunlan 1; Li, Zhiyong 1; Haq, Muhammad Abdul 1,3; Zhou, Yong 1; Wang, Dujin 1,2
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2017-08-01
卷号	77 页码:76-83
关键词	Poly(Vinyl Alcohol) Hydroxyapatite Gradient Hydrogel Electrophoresis Articular Cartilage
英文摘要	Bilayered poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) composite hydrogels with anisotropic and gradient mechanical properties were prepared by the combination of directional freezing-thawing (DFT) and electrophoresis method. Firstly, PVA hydrogels with aligned channel structure were prepared by the DFT method. Then, HA nanoparticles were in situ synthesized within the PVA hydrogels via electrophoresis. By controlling the time of the electrophoresis process, a bilayered gradient hydrogel containing HA particles in only half of the gel region was obtained. The PVA/HA composite hydrogel exhibited gradient mechanical strength depending on the distance to the cathode. The gradient initial tensile modulus ranging from 0.18 MPa to 027 MPa and the gradient initial compressive modulus from 033 MPa to 0.51 MPa were achieved. The binding strength of the two regions was relatively high and no apparent internal stress or defect was observed at the boundary. The two regions of the bilayered hydrogel also showed different osteoblast cell adhesion properties. (C) 2017 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38938]
专题	化学研究所_工程塑料实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Engn Plast, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Karachi, Dept Food Sci & Technol, Lab Food Engn, Karachi, Pakistan
推荐引用方式 GB/T 7714	Su, Cui,Su, Yunlan,Li, Zhiyong,et al. In situ synthesis of bilayered gradient poly(vinyl alcohol)/hydroxyapatite composite hydrogel by directional freezing-thawing and electrophoresis method[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,77:76-83.
APA	Su, Cui,Su, Yunlan,Li, Zhiyong,Haq, Muhammad Abdul,Zhou, Yong,&Wang, Dujin.(2017).In situ synthesis of bilayered gradient poly(vinyl alcohol)/hydroxyapatite composite hydrogel by directional freezing-thawing and electrophoresis method.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,77,76-83.
MLA	Su, Cui,et al."In situ synthesis of bilayered gradient poly(vinyl alcohol)/hydroxyapatite composite hydrogel by directional freezing-thawing and electrophoresis method".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 77(2017):76-83.