Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect

	Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect
	Jiang, Liguo 1,2,3; Cao, Siqin 2,3; Cheung, Peter Pak-Hang 4; Zheng, Xiaoyan 2; Leung, Chris Wai Tung 2; Peng, Qian 5; Shuai, Zhigang 6; Tang, Ben Zhong 2,3,4,7; Yao, Shuhuai 3,7,8; Huang, Xuhui 2,3,7
刊名	NATURE COMMUNICATIONS
	2017-05-31
卷号	8
英文摘要	The hydrophobic interaction drives nonpolar solutes to aggregate in aqueous solution, and hence plays a critical role in many fundamental processes in nature. An important property intrinsic to hydrophobic interaction is its cooperative nature, which is originated from the collective motions of water hydrogen bond networks surrounding hydrophobic solutes. This property is widely believed to enhance the formation of hydrophobic core in proteins. However, cooperativity in hydrophobic interactions has not been successfully characterized by experiments. Here, we quantify cooperativity in hydrophobic interactions by real-time monitoring the aggregation of hydrophobic solute (hexaphenylsilole, HPS) in a microfluidic mixer. We show that association of a HPS molecule to its aggregate in water occurs at sub-microsecond, and the free energy change is -5.8 to -13.6 kcal mol(-1). Most strikingly, we discover that cooperativity constitutes up to 40% of this free energy. Our results provide quantitative evidence for the critical role of cooperativity in hydrophobic interactions.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38373]
专题	化学研究所_有机固体实验室
作者单位	1.Hong Kong Univ Sci & Technol, Inst Adv Study, Hong Kong, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China 3.HKUST Shenzhen Res Inst, Hitech Pk, Shenzhen 518057, Peoples R China 4.Hong Kong Univ Sci & Technol, Div Biomed Engn, Hong Kong, Hong Kong, Peoples R China 5.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China 6.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 7.Hong Kong Univ Sci & Technol, Hong Kong Branch, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Hong Kong, Peoples R China 8.Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Liguo,Cao, Siqin,Cheung, Peter Pak-Hang,et al. Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect[J]. NATURE COMMUNICATIONS,2017,8.
APA	Jiang, Liguo.,Cao, Siqin.,Cheung, Peter Pak-Hang.,Zheng, Xiaoyan.,Leung, Chris Wai Tung.,...&Huang, Xuhui.(2017).Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect.NATURE COMMUNICATIONS,8.
MLA	Jiang, Liguo,et al."Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect".NATURE COMMUNICATIONS 8(2017).