Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment

	Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment
	Yang, Xi 1; Tong, Jun 2; Guo, Liemei 1; Qian, Zhongrun 1; Chen, Qixian 3; Qi, Ruogu 4; Qiu, Yongming 1
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2017
卷号	13 期号:1 页码:287-296
关键词	Natural Toxin Liposome Picoplatin Cantharidin Drug Delivery Neuroblastoma
英文摘要	Neuroblastoma (NB) is one of the most commonly seen malignancies in childhood and infancy. Cantharidin is a highly potent natural toxin that possesses potent anti-tumor properties on various cancers including NB. However, exposure to cantharidin can cause severe chemical burns and application of cantharidin for cancer therapy is limited. Here we report a strategy of bundling cantharidin within a hybrid platinum (IV) prodrug conjugate. This hydrophobic drug conjugate, ie, CanPt can be further formulated into liposome for drug delivery to minimize the exposure of cantharidin to normal cells for efficient chemotherapeutic agent against NB. (C) 2016 Elsevier Inc. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38202]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Neurosurg, South Campus, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Nephrol, Shanghai, Peoples R China 3.Chinese Acad Sci, Suzhou Inst Biomed Engn, Key Lab Biomed Diagnost, Suzhou, Peoples R China 4.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xi,Tong, Jun,Guo, Liemei,et al. Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(1):287-296.
APA	Yang, Xi.,Tong, Jun.,Guo, Liemei.,Qian, Zhongrun.,Chen, Qixian.,...&Qiu, Yongming.(2017).Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(1),287-296.
MLA	Yang, Xi,et al."Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.1(2017):287-296.