Reagent-controlled enantioselectivity switch for the asymmetric fluorination of beta-ketocarbonyls by chiral primary amine catalysis

	Reagent-controlled enantioselectivity switch for the asymmetric fluorination of beta-ketocarbonyls by chiral primary amine catalysis
	You, Yang'en 1,2; Zhang, Long 1,2,3; Luo, Sanzhong 1,2,3
刊名	CHEMICAL SCIENCE
	2017
卷号	8 期号:1 页码:621-626
英文摘要	A reagent-controlled enantioselectivity switch was uncovered in the asymmetric alpha-fluorination of beta-ketocarbonyls by a chiral primary amine catalyst. By a simple swap of fluorination reagents, both enantiomers of the quaternary fluorination adducts could be obtained with good yields and high enantioselectivity. Mechanistic studies disclosed dual H-bonding and electrostatic stereocontrolling modes for the catalysis.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38013]
专题	化学研究所_分子反应动力学实验室
作者单位	1.Chinese Acad Sci, Key Lab Mol Recognit & Funct, Inst Chem, BNLMS, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
推荐引用方式 GB/T 7714	You, Yang'en,Zhang, Long,Luo, Sanzhong. Reagent-controlled enantioselectivity switch for the asymmetric fluorination of beta-ketocarbonyls by chiral primary amine catalysis[J]. CHEMICAL SCIENCE,2017,8(1):621-626.
APA	You, Yang'en,Zhang, Long,&Luo, Sanzhong.(2017).Reagent-controlled enantioselectivity switch for the asymmetric fluorination of beta-ketocarbonyls by chiral primary amine catalysis.CHEMICAL SCIENCE,8(1),621-626.
MLA	You, Yang'en,et al."Reagent-controlled enantioselectivity switch for the asymmetric fluorination of beta-ketocarbonyls by chiral primary amine catalysis".CHEMICAL SCIENCE 8.1(2017):621-626.