A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.

doi:10.1080/14786419.2017.1396594

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 省部共建新疆特有药用资源利用重点实验室

	A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.
	Liu, XX (Liu, Xixi)[ 1,2,3 ]; Aisa, HA (Aisa, Haji Akber)[ 1,2 ]; Xin, XL (Xin, Xuelei)[ 1,2 ]
刊名	Natural product research
	2019
卷号	33 期号:4 页码:472-476
关键词	Nigella sativa var hispidula fatty acid ester phenolic compounds anti-PTP1B activity
ISSN号	1478-6419
DOI	10.1080/14786419.2017.1396594
英文摘要	A new fatty acid ester (1) and seven known phenolic compounds, i.e. salfredin B11 (2), nigephenol C (3), nigephenol B (4), acetovanillion (5), p-hydroxybenzoic acid (6), p-hydroxy-acetophenone (7) and p-hydroxybenzaldehyde (8), were isolated from the seeds of Nigella sativa var. hispidula. Among them, compounds 5, 7 and 8 were isolated from Nigella for the first time. Their structures were elucidated with HR-ESI-MS, 1D and 2D NMR spectra. Evaluation of the isolated compounds on protein tyrosine phosphatase (PTP1B) assay indicated that although compounds 2-8 show no promising anti-PTP1B activities, compound 1 possess anti-PTP1B activity with an IC50 value of 7.38±0.14muM in vitro.
WOS记录号	WOS:000465153400003
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/5485]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室新疆理化技术研究所_资源化学研究室
通讯作者	Xin, XL (Xin, Xuelei)[ 1,2 ]
作者单位	1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China 3.Univ Chinese Acad Sci, Beijing, PR, Peoples R China
推荐引用方式 GB/T 7714	Liu, XX ,Aisa, HA ,Xin, XL . A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.[J]. Natural product research,2019,33(4):472-476.
APA	Liu, XX ,Aisa, HA ,&Xin, XL .(2019).A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity..Natural product research,33(4),472-476.
MLA	Liu, XX ,et al."A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.".Natural product research 33.4(2019):472-476.