New cytotoxic steroid from Stachyurus himalaicus var. himalaicus

	New cytotoxic steroid from Stachyurus himalaicus var. himalaicus
	Wang, Yun-Song ; Yang, Jing-Hua ; Luo, Shi-De ; Zhang, Hong-Bin ; Li, Liang
刊名	MOLECULES
	2007-03-01
卷号	12 期号:3 页码:536-542
关键词	Steroids Stachyurus Himalaicus Var. Himalaicus Stachyuraceae Cytotoxity
ISSN号	1420-3049
通讯作者	wangys99@hotmail.com ; yangjh@ynu.edu.cn ; shideluo@hotmail.com ; zhanghb@ynu.edu.cn ; liliang5758@hotmail.com
文献子类	Article
英文摘要	A phytochemical study of the ethanolic extract of Stachyurus himalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 mu g/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.
学科主题	Chemistry, Organic
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000245437400023
公开日期	2012-04-18
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/5589]
专题	昆明植物研究所_离退休
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yun-Song,Yang, Jing-Hua,Luo, Shi-De,et al. New cytotoxic steroid from Stachyurus himalaicus var. himalaicus[J]. MOLECULES,2007,12(3):536-542.
APA	Wang, Yun-Song,Yang, Jing-Hua,Luo, Shi-De,Zhang, Hong-Bin,&Li, Liang.(2007).New cytotoxic steroid from Stachyurus himalaicus var. himalaicus.MOLECULES,12(3),536-542.
MLA	Wang, Yun-Song,et al."New cytotoxic steroid from Stachyurus himalaicus var. himalaicus".MOLECULES 12.3(2007):536-542.