Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear

doi:10.3390/molecules23071797

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear
	Cheng, Li-Zhi 1,2; Qin, Fu-Ying 2,3; Ma, Xiao-Chi 4; Wang, Shu-Mei 1; Yan, Yong-Ming 2; Cheng, Yong-Xian 1,2
刊名	MOLECULES
	2018-07-01
卷号	23 期号:7 页码:10
关键词	Ganoderma cochlear meroterpenoids cytotoxic activity N-acetyltransferase
ISSN号	1420-3049
DOI	10.3390/molecules23071797
英文摘要	Seven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC9, A549) and N-acetyltransferase inhibitory property. The results show that (+)-gancochlearol C could inhibit N-acetyltransferase with an IC50 value of 5.29 M. In addition, ganomycin F was found to show moderate activity against the H1975 human lung cancer cell line, with an IC50 value of 19.47 M.
资助项目	National Key Research and Development Program of China[2017YFA0503900] ; National Science Fund for Distinguished Young Scholars[81525026] ; NSFC-Joint Foundation of Yunnan Province[U1702287] ; National Natural Science Foundation of China[21472199]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000445301800300
资助机构	National Key Research and Development Program of China ; National Science Fund for Distinguished Young Scholars ; NSFC-Joint Foundation of Yunnan Province ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/62790]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 2.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116044, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,et al. Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear[J]. MOLECULES,2018,23(7):10.
APA	Cheng, Li-Zhi,Qin, Fu-Ying,Ma, Xiao-Chi,Wang, Shu-Mei,Yan, Yong-Ming,&Cheng, Yong-Xian.(2018).Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.MOLECULES,23(7),10.
MLA	Cheng, Li-Zhi,et al."Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear".MOLECULES 23.7(2018):10.