Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.

doi:10.1016/j.fitote.2017.11.020

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.
	Yao, Jian-Neng 1,3; Chen, Lin 2; Chen, He-Ping 2; Zhao, Zhen-Zhu 1,3; Zhang, Shuai-Bing 1,3; Huang, Ying 1,3; Tang, Yang 1,3; Isaka, Masahiko 4; Li, Zheng-Hui 2; Feng, Tao 2
刊名	FITOTERAPIA
	2018-03-01
卷号	125 页码:227-234
关键词	Stereum Sp. Lanostane Triterpenoid Nmr Calculation Cytotoxicity
ISSN号	0367-326X
DOI	10.1016/j.fitote.2017.11.020
英文摘要	Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Sterewn sp. Compounds 3 and 4 are structurally characterized as intact lanostanetype triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is a 24methylene-lanostane. The structures of these new compounds were established based on detailed 1D and 2D NMR spectroscopic analyses, along with quantum chemical NMR calculations. All isolates were evaluated for their in vitro cytotoxicities against five human tumor cell lines (including HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines). Compound 4 showed moderate cytotoxic activities against tumor cell lines SMMC-7721 and SW480 with IC50 values of 9.1 and 9.8 mu M, respectively.
语种	英语
WOS记录号	WOS:000425560500034
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60552]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Natl Ctr Genet Engn & Biotechnol BIOTEC, 113 Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathumthani, Thailand
推荐引用方式 GB/T 7714	Yao, Jian-Neng,Chen, Lin,Chen, He-Ping,et al. Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.[J]. FITOTERAPIA,2018,125:227-234.
APA	Yao, Jian-Neng.,Chen, Lin.,Chen, He-Ping.,Zhao, Zhen-Zhu.,Zhang, Shuai-Bing.,...&Liu, Ji-Kai.(2018).Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp..FITOTERAPIA,125,227-234.
MLA	Yao, Jian-Neng,et al."Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.".FITOTERAPIA 125(2018):227-234.