Saussurea ramchaudharyi Ghimire & Rana, a new species from the alpine slopes of northwestern region of Nepal is described and illustrated. It is closely related to S. topkegolensis and S. gossypiphora, both of which are the members of S. subgen. Eriocoryne, but differs by having much shorter (2.5-3 cm vs. >= 4 cm) stem, greenish purple upper leaves extending half of length of capitula, broadly campanulate involucres, 4-seriate phyllaries, apically glabrous inner phyllaries, much smaller achene (<= 2 mm vs. > 2 mm) and inner bristles of pappus shorter than corolla. The species is categorized as Critically Endangered based on the IUCN Red List categories and criteria.