(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3

doi:10.1039/c7ra04862a

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3
	Luo, Qi1,2 ; Wang, Zhen 3; Luo, Jin-Feng 3; Tu, Zheng-Chao 3; Cheng, Yong-Xian 1,4
刊名	RSC ADVANCES
	2017
卷号	7 期号:60 页码:38037-38043
关键词	(+/-)-lingzhiol Biosynthesis Lucidum Potent Ddr1
ISSN号	2046-2069
DOI	10.1039/c7ra04862a
英文摘要	Applanatumines B-D (1-3), three pairs of dimeric meroterpenoid enantiomers featuring the presence of a 6-oxo-4,4a, 5,5a, 6,8,8a, 8b-octahydrofuro[3',4':4,5] cyclopenta[1,2-b] pyran-3-carbaldehyde structure core, were isolated from the fruiting bodies of Ganoderma applanatum. Their structures and absolute configurations were assigned by using spectroscopic methods and ECD calculations. Biological evaluation found that all the compounds are JAK3 inhibitors. In addition, the enantiomers of 1 are active towards DDR1 with IC50 values of 8.2 + 0.8 mu M and 6.9 + 0.8 mu M. Finally, a plausible biogenic pathway for compounds 1-3 was proposed.
学科主题	Chemistry, Multidisciplinary
语种	英语
WOS记录号	WOS:000407305200066
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/54979]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China 3.Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Biocomp, Drug Discovery Pipeline, Guangzhou 510530, Guangdong, Peoples R China 4.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China
推荐引用方式 GB/T 7714	Luo, Qi,Wang, Zhen,Luo, Jin-Feng,et al. (+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3[J]. RSC ADVANCES,2017,7(60):38037-38043.
APA	Luo, Qi,Wang, Zhen,Luo, Jin-Feng,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2017).(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3.RSC ADVANCES,7(60),38037-38043.
MLA	Luo, Qi,et al."(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3".RSC ADVANCES 7.60(2017):38037-38043.