Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum

doi:10.1021/np100059m

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum
	Lu, Zhenyu 2; Zhu, Huajie 3; Fu, Peng 2; Wang, Yi 2; Zhang, Zhihua 1; Lin, Haipeng 1; Liu, Peipei 2; Zhuang, Yibin 2; Hong, Kui 1; Zhu, Weiming 2
刊名	JOURNAL OF NATURAL PRODUCTS
	2010-05-01
卷号	73 期号:5 页码:911-914
关键词	Kaurene Diterpenoids Taihangensis Constituents Leucantha
ISSN号	0163-3864
DOI	10.1021/np100059m
文献子类	Article
英文摘要	Two new polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A (1) and B (2), and two new phenolic bisabolane sesquiterpenoids, (S)-(+)-11-dehydrosydonic acid (3) and (7S,11S)-(+)12-acetoxysydonic acid (4), along with two known compounds, (S)-(+)-sydonic acid (5) and diorcinol (6), were isolated from the metabolites of the marine-derived fungus Penicillium expansum 091006 endogenous with the mangrove plant Excoecaria agallocha. On the basis of spectroscopic analysis, chemical transformation, and theoretical calculation, the structures of 1-4 were elucidated as (S)-(+)-2[3-hydroxy-4-(2- methoxy-6-methylheptan-2-yl)benzyl]-5-(3-hydroxy-5-methylphenoxy)-3-methylphenol, S-(+)-2-[3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzyl]-5-(3-hydroxy-5-methylphenoxy)-3-methylphenol, (S)-(+)-3-hydroxy-4-(2-hydroxy-6-methylhept-6-en-2-yl)benzoic acid, and 4-[(2S,6S)-7-acetoxy-2-hydroxy-6-methylheptan-2-yl]-3-hydroxybenzoic acid, respectively. Expansol A (1) exhibited moderate cytotoxicity against the HL-60 cell line with an IC(50) value of 15.7 mu M, and expansol B (2) inhibited the proliferation of A549 and HL-60 cells with IC(50) values of 1.9 and 5.4 mu M, respectively.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	EXCOECARIA-AGALLOCHA ; SYDONIC ACID ; SPONGE ; SESQUITERPENES ; PARAHIGGINSIA ; ELUCIDATION ; METABOLITES ; DITERPENES ; ROTATIONS ; ALKALOIDS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000278080900022
资助机构	National Basic Research Program of China [2010CB833800]; National Natural Science Foundation of China [30670219, 30770235]; Project of Chinese National Programs for High Technology Research and Development [2007AA09Z447]; Program for Social Profit of China Ministry of Science and Technology [2004D1B3J072]; Key Laboratory of Marine Drugs of Ministry of Education [KLMD-OUC-200607]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4894]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Trop Agr Sci, Inst Trop Biol Sci & Biotechnol, Haikou 571101, Peoples R China 2.Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Lu, Zhenyu,Zhu, Huajie,Fu, Peng,et al. Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(5):911-914.
APA	Lu, Zhenyu.,Zhu, Huajie.,Fu, Peng.,Wang, Yi.,Zhang, Zhihua.,...&Zhu, Weiming.(2010).Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum.JOURNAL OF NATURAL PRODUCTS,73(5),911-914.
MLA	Lu, Zhenyu,et al."Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum".JOURNAL OF NATURAL PRODUCTS 73.5(2010):911-914.