Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells

doi:10.1016/j.tet.2009.06.007

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells
	Xia, Chengfeng 1,2,3; Zhang, Wenpeng 1,2; Zhang, Yalong 1,2; Woodward, Robert L.1,2; Wang, Jinhua 1,2; Wang, Peng G.1,2
刊名	TETRAHEDRON
	2009-08-08
卷号	65 期号:32 页码:6390-6395
关键词	Natural Killer t Cells Alpha-galactosylceramide Biotin Cd1d
ISSN号	0040-4020
DOI	10.1016/j.tet.2009.06.007
文献子类	Article
英文摘要	When iNKT cells are stimulated by the CD1d presented exogenous alpha-galactosylceramide, a myriad of cytokines are released that trigger a variety of immune responses. However, the invisibility and poor aqueous Solubility of alpha-galactosylceramide during bioassays have rendered it difficult to study the aforementioned biological responses. Accordingly, a biotin-labelled alpha-galactosylceramide was prepared to facilitate detection of this antigen in the immune process. The problematic low solubility was also remedies via incorporation of a truncated acyl chain. (C) 2009 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Organic
WOS关键词	NKT CELLS ; CD1D ; RECOGNITION
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000268736900015
资助机构	Ohio State University
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4770]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA 2.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Xia, Chengfeng,Zhang, Wenpeng,Zhang, Yalong,et al. Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells[J]. TETRAHEDRON,2009,65(32):6390-6395.
APA	Xia, Chengfeng,Zhang, Wenpeng,Zhang, Yalong,Woodward, Robert L.,Wang, Jinhua,&Wang, Peng G..(2009).Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells.TETRAHEDRON,65(32),6390-6395.
MLA	Xia, Chengfeng,et al."Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells".TETRAHEDRON 65.32(2009):6390-6395.